中国科学院武汉病毒研究所研究员、博士生导师 / Professor, Wuhan Institute of Virology, Academy of Sciences

学习经历 / Education

1998-2001:中山大学生科院，微生物学 博士/ Ph.D. in Microbiology, Sun Yat-sen University, China.

1984-1987:云南大学生物系，微生物学 硕士 / M.S. in Microbiology, Yunnan University, China.

1980-1984：湖北大学生物系，生物学 学士 / B.S. in Biology, Hubei University, China.



工作经历 / Work Experience

1999-至今：中国科学院武汉病毒研究所研究员/ Professor, Wuhan Institute of Virology, CAS.

1999-2000：丹麦农业大学访问学者/Visiting Scholar, Royal Agricultural & Veterinary University, Denmark.

1996-1999：中国科学院武汉病毒研究所副研究员/Associate Professor，Wuhan Institute of Virology, CAS.

1996-1997：法国巴斯的研究所访问学者/ Visiting Scholar, CIRAD and Institut Pasteur, France.

1989-1995：中国科学院武汉病毒所助理研究员/Assistant researcher, Wuhan Institute of Virology, CAS.

1987-1989: 云南大学，微生物学助教/Assistant Lecture in Microbiology, Yunnan University, China.



学术兼职 / Committee and Broad Memberships

1. 中国微生物学会理事/Board Member, Chinese Society for Microbiology

2. 湖北省微生物学会副理事长/ Vice President, Hubei Society for Microbiology

3. 国家生物安全委员会委员/Member, National Committee of Laboratory Biosafety

4. 湖北生物工程学会常务理事/ Board Member, Hubei Society for Biotechnology

5. 美国微生物会会员/Member, American Microbiology Society

6. 中国科学院武汉病毒研究所学术委员会主任/ Directory, Academic Committee of Wuhan Institute of Virology, CAS

研究方向 / Research Interests

1． 研究登革热病毒、乙型脑炎病毒和西尼罗病毒的快速检测及病毒与宿主的相互作用关系/ Diagnosis technique development for virus detection and the interaction between aborvirus (DEN, JEV, WNV) and host mosquitoes.


2． 蚊虫病原微生物菌种及其基因资源，微生物基因组学和比较基因组学，杀蚊毒素蛋白特性和作用方式、杀蚊细菌的遗传改良和工程菌株的构建，新型细菌杀蚊制剂的研制及野生型和重组微生物对环境的安全性评估等/ Entomopathogenic bacteria (Bacillus thuringiensis and B. sphaericus) and insecticidal gene resources, microbial genomics and comparative genomics, insecticidal proteins and their mode of action, construction of engineering strains with higher toxicity and wider active spectrum.


3． 发展新的生物防治技术，建立和完善以生物防治为主的虫媒病毒媒介蚊虫综合防治体系/ Production, standardization and application of bio-pesticide and other microbial agents, resistance mechanism in target insects and the resistance management.

近期代表性学术论文 / Selected Recent Publications

1. Hu XM, Fan W, Han B, Liu HZ, Zheng DS, Li QB, Dong W, Yan JP, Gao MY, Berry C, Yuan ZM* (2008). Complete genome sequence of the mosquitocidal bacterium Bacillus sphaericus C3-41 and comparison with closely related Bacillus species, J. Bacteriol. 190: 2892–2902.

2. Zhou GP, Liu HZ, He J, Yuan YM, Yuan ZM* (2008). The occurrence of Bacillus cereus, B. thuringiensis and B. mycoides in Chinese pasteurized full fat milk. Int J Food Microbiol., 121:195–200.

3. Zhang JT, Yan JP, Zheng DS, Sun YJ, Yuan ZM* (2008). Expression of mel gene improves the UV resistance of Bacillus thuringiensis. J Appl Microbiol. 105: 151–157.

4. Hu XM, Li J li, Hansen BM, and Yuan ZM* (2008). Phylogenetic analysis and heterologous expression of surface layer protein SlpC of Bacillus sphaericus C3-41, Biosci Biotech Bioch, 72:1257-63.

5. Cai Yajun, Yan Jianpin, Hu Xiaomin, Han Bei, Yuan Zhiming* (2007). Improving the insecticidal activity against resistant Culex quinquefasciatus by expression of chitinase gene chiAC in Bacillus sphaericus. Appl Environ Microbiol., 73: 7744–7746.

6. Gareth Jones, Christina Nielsen-Leroux, Yankun Yang, Zhiming Yuan, Vinícius Fiúza Dumas, Rose Monnerat and Colin Berry* (2007). A new Cry toxin with a unique two-component dependency from Bacillus sphaericus. The FASEB Journal, 21:4112-20.

7. Yang Y, Wang L, Gaviria A, Yuan Z*, Berry C.*(2007), Proteolytic stability of insecticidal toxins expressed in recombinant Bacilli. Appl Environ Microbiol. 73:218-225.

8. Wei S, Cai Q, Cai Y, Yuan Z* (2007), Lack of cross-resistance to Mtx1 from Bacillus sphaericus in B. sphaericus-resistant Culex quinquefasciatus (Diptera: Culicidae). Pest Manag Sci. 63:190-193.

9. Wu Enying, Liang Jun, Yuan Yongming, Colin Berry, Yuan Zhiming* (2007). Characterization of a Cryptic Plasmid from Bacillus sphaericus Strain LP1-G, Plasmid, 57: 296-305.

10. Han Bei, Haizhou Liu, Xiaomin Hu, Yajun Cai, Dasheng Zheng, and Zhiming Yuan* (2007). Molecular characterization of a glucokinase with broad hexose specificity from Bacillus sphaericus strain C3-41, Appl. Environ. Microbiol. 73: 3581–3586.

11. Yunjun Sun, Wei Wei, Xuezhi Ding, Liqiu Xia, Zhiming Yuan* (2007). Detection of chromosomally located and plasmid-borne genes on 20-kb DNA fragments in parasporal crystals from Bacillus thuringiensis, Arch Microbiol. 188:327-332.

12. Yuan Yongming, Hu Xiaomin, Liu Haizhou, Bjarne Munk Hansen, Yan Jianping, Yuan Zhiming*(2007). Kinetics of plasmid transfer among Bacillus cereus group strains within lepidopteran larvae, Arch Microbiol. 187: 425-31.