工作经历 / Work Experience

2002.1～ 至今 中国科学院武汉病毒研究所、“百人计划”研究员/ Professor of Wuhan Institute of Virology , Chinese Academy of science

2000.4～至今 湖南师范大学生命科学院、特聘教授/ Chair Professor of College of Life Science, Hunan Normal University

2005.5～ 至今 上海生物制品研究所、研究员/ Professor of Shanghai Institute of Biological Products

1997.3～2000.3 日本国立感染症研究所、协力研究员/ Senior researcher of National Institute of Infectious Diseases of Japan

1988.7～1989.4 上海市第四人民医院、外科医师/ Surgeon of Fourth People's Hospital of Shanghai

学术兼职 / Committee and Broad Memberships

1. 国家自然科学基金委员会学科评审组专家 / Member, Grant Review Committee of National Natural Science Foundation of China

2. 中国微生物学会医学微生物学与免疫学专业委员会副主任委员/ vice President, the Professional Committee of medical microbiology and immunology of Society for Microbiology of China


研究方向 / Research Interests

主要研究方向有：流感病毒疫苗的应用及其基础研究。包括DNA疫苗、重组疫苗、亚单位疫苗、灭活疫苗、粘膜疫苗和疫苗佐剂等；禽流感病毒流行病学 调查和流感病毒跨种(族)感染机理研究。目前承担的课题有”百人计划”项目、国家“863”研究一项、国家重大科技攻关项目一项、院创新方向性课题一项、国家自然科学基金资助项目和省科技厅、教育厅研究专项基金。
The main research directions include: the application and basic research about the influenza vaccine. They include DNA vaccine, recombinant vaccine, subunit vaccine, inactivated vaccine, mucosal vaccine and vaccine adjuvant and so on; the avian flu virus epidemiological investigation and the mechanism research of the influenza virus cross-species infection. Further study the composition of the storage source and animal chain of the influenza virus, understand the relationships between the genetic variation and the virus virulence.


近期代表性学术论文 / Selected Recent Publications

1. Wang Fuyan, Yang Wen, Fang Fang, Chang Haiyan, Yu Ping, Chen Ze Essential sequence of influenza B virus hemagglutinin DNA to provide protection against lethal homologous viral infection DNA and cell biology 2008 May 8. [Epub ahead of print] (通讯作者)

2. Chen J, Zhang F, Fang F, Chang H, Chen Z. Vaccination with hemagglutinin or neuraminidase DNA protects BALB/c mice against influenza virus infection in presence of maternal antibody. BMC Infect Dis. 2007 Oct 16;7(1):118 (通讯作者)

3. Qiu M, Fang F, Chen Y, Wang H, Chen Q, Chang H, Wang F, Wang H, Zhang R,Chen Z. Protection against avian influenza H9N2 virus challenge by immunization with hemagglutinin- or neuraminidase-expressing DNA in BALB/c mice. Biochem Biophys Res Commun. 2006 May 19;343(4):1124-31. (通讯作者)

4. Li X, Fang F, Song Y, Yan H, Chang H, Sun S, Chen Z. Essential sequence of influenza neuraminidase DNA to provide protection against lethal viral infection. DNA Cell Biol. 2006 Apr;25(4):197-205. (通讯作者)

5. Fenghua Zhang, Jianjun Chen, Fang Fang, Yu Zhou, Jian Wu, Haiyan Chang, Ran Zhang, Fuyan Wang, Xiaoman Li, Hanzhong Wang, Guohua Ma and Ze Chen. Maternal immunization with both hemagglutinin- and neuraminidase-expressing DNAs provide an enhanced protection against a lethal influenza virus challenge in infant and adult mice. DNA Cell Biology. 2005; 24(11):758-765. (通讯作者)

6. Jianjun Chen, Fang Fang, Xiangzhong Li, Haiyan Chang and Ze Chen. Protection against influenza virus infection in BALB/c mice immunized with a single dose of neuraminidase-expressing DNAs by electroporation. Vaccine. 2005;23(34):4322-4328. (通讯作者)

7. Zhu Q, Chang H, Chen Y, Fang F, Xue C, Zhang F, Qiu M, Wang H, Wang B, Chen Z. Protection of inactivated influenza virus vaccine against lethal influenza virus infection in diabetic mice. Biochem Biophys Res Commun. 2005 Apr 1;329(1):87-94.(通讯作者).

8. Tang L, Zhu Q, Qin E, Yu M, Ding Z, Shi H, Cheng X, Wang C, Chang G, Zhu Q, Fang F, Chang H, Li S, Zhang X, Chen X, Yu J, Wang J, Chen Z. Inactivated SARS-CoV vaccine prepared from whole virus induces a high level of neutralizing antibodies in BALB/c mice. DNA Cell Biol. 2004 Jun;23(6):391-4.(通讯作者).

9. Ze C, Kurata T, Tamura S. Identification of effective constituents of influenza vaccine by immunization with plasmid DNAs encoding viral proteins. Jpn J Infect Dis. 2000 Dec;53(6):219-28. Review.

10. Chen Z, Kadowaki S, Hagiwara Y, Yoshikawa T, Sata T, Kurata T, Tamura S. Protection against influenza B virus infection by immunization with DNA vaccines. Vaccine. 2001 Jan 8;19(11-12):1446-55.