章晓联教授，博导、教育部“新世纪人才” |
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病毒学国家重点实验室，教授 / Professor, State Key Laboratory of Virology, China.
武汉大学“珞珈学者”特聘教授 / Luojia Professor of Wuhan University, China.
武汉大学基础医学院免疫系，教授、博士生导师 / Professor, Wuhan University
School of Mdicine, Dept. of Immunology, China..
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学习经历 / Education
1997-20001：美国马里兰大学 糖蛋白的生化与分子生物学 博士后 / Postdoctoral Associate in Biochemistry and Molecular Biology of Glycoprotein, University of Maryland at College Park, USA.
1993-1997：香港科技大学 生物化学 博士 / Ph.D. in Biochemistry, Hong Kong University of Science and Technology, Hong Kong
1986-1989：武汉大学 病毒学 硕士 / M.S. in Virology, Wuhan University, China.
1982-1986：武汉大学 微生物学 学士 / B.S. in Microbiology, Wuhan University, China.
工作经历 / Work Experience
2006-至今：武汉大学“珞珈学者”特聘教授 / Luojia Professor of Wuhan University.
2005-至今：病毒学国家重点实验室，教授 /Professor, State Key Laboratory of Virology, China.
2002-至今：武汉大学医学院过敏及免疫相关疾病湖北省重点实验室免疫研究室主任教授 / Professor, Hubei Province Key Laboratory of Allergy and Immunology, Wuhan University School of Medicine, China
2002-至今：武汉大学医学院 免疫系主任教授 / Chair Professor of Immunology, Wuhan University School of Medicine, China
2001-2002 武汉大学医学院 医学微生物及免疫教研室，教授 / Chair Professor of Immunology, Wuhan University School of Medicine, China
1989-1993：湖北医科大学，医学微生物及免疫教研室 讲师/ Lecture,, Wuhan University, Wuhan, China.
2004-2004：日本福岛医科大学生化系（II），访问学者/ Visiting Scholar,, Fukushima Medical University, Biochemistry Department (II), Japan.
学术兼职 / Committee and Broad Memberships
1. 中华医学会武汉市微生物及免疫学会副理事长 / Vice President, Chinese Medical Committee, Wuhan Medical Microbiology and Immunology committee
2. 武汉市免疫学会副理事长 / Vice President, Wuhan Medical Immunology committee
3. 中国生物化学与分子生物学学会糖复合物专业委员会委员/ Member, Committee of the Chinese Biochemistry and Molecular Biology, Glyco-conjugation professional committee, China
4. 中华医学会微生物及免疫学会青年委员/Member, Chinese Medical Microbiology and Immunology committee, Chinese Medical Committee,
5. 《中国病毒学》杂志编委/ Member of editorial board, Virologica Sinica
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研究方向 / Research Interests
1． 以人类重要胞内病原体（丙型肝炎病毒、伤寒沙门氏菌和结核杆菌）为主要研究对象，重点研究它们的感染免疫机制、并发展其诊断、预防和免疫治疗技术 / Molecular mechanisms of infection and immunity caused by important human intracellular pathogens including Hepatitis C Virus,Salmonella bacteria and Mycobacterium tuberculosis.
2． 研究感染性疾病和肿瘤的糖免疫学基础与应用研究/ Basic and application investigation of glyco-immunology for infectious diseases and tumors
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近期代表性学术论文 / Selected Recent Publications
1. Li DQ, Li Y, Wu X, Li Q, Yu J, Gen J, Zhang XL*. 2008. Knockdown of Mgat5 inhibits breast cancer cell growth with activation of CD4+T cells and macrophages. J Immunol. 180（5）：3158-3165.
2. Liu M, Chen H, Luo F, Li P, Pan Q, Xia B, Qi Z, Ho WZ, Zhang XL*. 2007. Deletion of N-glycosylation of hepatitis C virus envelope protein E1 enhances specific cellular and humoral immune responses, Vaccine, 25: 6572-6580 (IF: 3.159)
3. Li PF, Wan Q, Feng Y, Liu M, Wu JG, Chen XW, Zhang XL*. 2007. Engineering of N-glycosylation of Hepatitis C Virus Envelope Protein E2 Enhances T cell responses for DNA immunization, Vaccine, 25: 1544-1551.
4. Luo F, Feng Y, Liu M, Li P, Pan Q, Tunje JV, Xia B, Wu J, Zhang XL*. 2007. A type IVB pili operon promoter controlling nucleocapsid gene expression of SARS-CoV in Salmonella elicits full immune response by intranasal vaccination. Clin Vaccine Immunol, 14: 990-997
5. Chen F, Zhou J, Luo F, Mohammed AB and Zhang XL*. 2007. Aptamer from whole-bacterium SELEX as new therapeutic reagent against virulent Mycobacterium tuberculosis，Biochem Biophys Res Commun， 357:743-748
6. Zhang XL* . 2006. Roles of Glycans and Glycopeptides in Immune System and Immune-Related Diseases, Curr. Med. Chem. 13: 1141-1147.
7. Ye XS, Sun F, Liu M, Li Q, Wang Y, Zhang L-H, Zhang XL*, 2005, Synthetic Iminosugar derivatives as new potential Immunosuppressive agents, J. Med. Chem. 48: 3688-3691.
8. Pan Q, Zhang XL*, Wu H-Y, He P-W, Wang F, Zhang M-S, Hu J-M, Xia B, Wu J, 2005, Identification of aptamers that preferentially bind the type IVB pili and inhibit human monocytic cell invasion by Salmonella Typhi, Antimicrob Agents Chemother. 49 (10): 4052-4060.
9. Ｗu H-Y, Zhang XL*, Pan Q, Wu J. 2005, Functional selection of a type IV pili-binding peptide that specifically inhibits Salmonella Typhi adhesion to/invasion of human monocytic cells. Peptides 26(11): 2057-2063.
10. Wang F, Zhang XL*, Zhou Y, Ye L, Qi Z, Wu J. 2005. Type IVB piliated Salmonella Typhi enhance IL-6 and NF-?? production in human monocytic THP-1 cells through activation of protein kinase C, Immunobiology210(5): 283-293.
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联系方式 / Contact Information
电话 / Tel: 86-27-68759986; 86-27-87331183传真 / Fax: 86-27-87336380
电子邮箱 / E-mail: zhangXL65@nwhu.edu.cn or zhangXL65@hotmail.com
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