学习经历 / Education

1996-2001：芬兰赫尔新基大学 病毒学 博士后 / Postdoctoral Associate in Virology, Helsinki University, Finland.

1991-1995：德国布伦瑞克理工大学 微生物学 博士 / Ph.D. in Microbiology, Braunschwaiger University of Technology, Germany.

1985-1988：中国农业科学院研究生院和中国科学院微生物所 病毒学 硕士 / M.S. in Virology, Graduate School, CAAS and Institute of Microbiology, CAS, Beijing, China.

1990-1991：同济大学留德预备部 / German Centre, Tongji University, Shanghai.

1981-1985：南京农业大学 学士 / B.S., Nanjing Agricultural University, China.


工作经历 / Work Experience

2002 -至今：武汉大学生科院 教授，博导，副院长 / Professor, College of Life Sciences, Wuhan University, Wuhan, China.

1996-2002：芬兰赫尔新基大学 博士后，senior researcher，docent / Institute of Biotechnology, University of Helsinki, Finland.

1991-1995：德国联邦生物化学和植物病毒研究所/ Researcher，Federal Institute for Biochemistry & Plant Virology, BBA, Braunschweig, Germany.

1988-1991：中国农业科学院植物病毒研究室 助研/ Assistant Research Fellow, Plant Virology Laboratory， Chinese Academy of Agricultural Sciences。.

研究方向 / Research Interests

1．RNA病毒（冠状病毒和丙肝病毒）的基因组复制及免疫逃逸的分子机制 / Molecular mechanisms of genome replication and immune escape of RNA viruses (coronavirus and hepatitis C virus).

2．基于RNA干扰（RNAi）的艾滋病毒基因治疗/ RNAi-based genetic therapy of HIV/AIDS.

近期代表性学术论文 / Selected Recent Publications

1. Hussain Snawar, Ji’an Pan, Yu Chen, Yalin Yang, Jing Xu, Yu Peng, Ying Wu, Chaoyang Li, Ying Zhu, Po Tien, Deyin Guo. (2005). Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus. Journal of Virology 79:5288-95

2. Zhaoyang Li, Yong Xiong, Yu Peng, Ji’an Pan, Yu Chen, Xiaoyun Wu, Snawar Hussain, Po Tien, Deyin Guo. (2005). Specific inhibition of HIV-1 replication by short hairpin RNAs targeting human cyclin T1 without inducing apoptosis. FEBS Lett. 579, 3100-6.

3. Zuoxiang Xiao, Yong Xiong, Lindi Tan, Elana Ehrlich, Deyin Guo and Xiao-Fang Yu (2007). Characterization of a Novel Cullin5 Binding Domain in HIV-1 Vif. Journal of Molecular Biology 373, 541-550.

4. Ping Chen, Miao Jiang, Tao Hu, Qingzhen Liu, Xiaojiang S. Chen, Deyin Guo(2007)Biochemical characterization of exoribonuclease encoded by SARS coronavirus. Journal of Biochemistry & Molecular Biology 40 (5), 649-655.

5. Xiaoyun Wu, You Zhou, Ke Zhang, Qingzhen Liu & Deyin Guo (2008). Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B. FEBS Lett. 2008 May 30. [Epub ahead of print]

6. Junwei Li, Hui Cai, Qingzhen Liu & Deyin Guo (2008). Molecular and pathological characterization of two H5N1 avian influenza viruses isolated from wild ducks. Virus Genes Jun 3. [Epub ahead of print]

7. Yaling Yang, Quan Wang, Deyin Guo (2008). A Novel Strategy for Analyzing RNA-Protein Interactions by Surface Plasmon Resonance Biosensor. Molecular Biotechnology. 2008 May 9. [Epub ahead of print]

8. Xiaoyun Wu, Musarat Ishaq, Jiajie Hu, Deyin Guo (2008). HCV NS3/4A protein activates HIV-1 transcription from its long terminal repeat. Virus Research 135, 155-160.

9. Musarat Ishaq, Jiajie Hu, Xiaoyun Wu, Qingzhen Liu and Deyin Guo. (2008). Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis. Molecular Biotechnology. 2008 Feb 8 [Epub ahead of print]

10. Deyin Guo, Minna-Leena Rajam?ki & Jari Valkonen. (2008). Protein-protein interactions: the yeast two-hybrid system. Methods in Molecular Biology 451,421-439.