病毒学国家重点实验室

邹国林教授，博导

武汉大学生命科学学院，教授、博士生导师 / Professor, College of Life Sciences, Wuhan University.

学习与工作经历 / Education and Work Experience

1983-至今：武汉大学生物系（现生科院），教师 / Faculty, Wuhan University, China

其中，1991-1992：美国西东大学化学系，访问学者 / Visiting Scholar, in Chemistry, Seton Hall University , USA

1980-1983：武汉大学生物系生物化学专业硕士 / M.S. in Biochemistry, Wuhan University, China

1979-1980：武汉大学生物系生化专业进修生 / Visiting Scholar, in Biochemistry, Wuhan University, China.

1972-1979：武汉市81中，教师 / Faculty, Wuhan No. 81 high school

1970-1972：解放军8199部队锻炼 / Training in the Chinese People's Liberation Army 8199

1965-1970：武汉大学生物系微生物学专业本科生 / B.S. in Microbiology, Wuhan University, China

学术与社会兼职 / Committee and Social Memberships

1. 湖北省暨武汉生物物理学会理事长 / President, Hubei / Wuhan Society for Biophysics

2. 湖北省中小企业共性技术生物应用研发推广中心主任 / Director, Center of Common Application of Biological Technology Research and Development Promotion of Small and Medium Enterprises in Hubei Province

3. 工业微生物湖北省重点实验室学术委员会主任 / Director, Broad Committee of the Hubei Provincial Key Laboratory of Industrial Microbiology

4. 中药资源与中药复方教育部重点实验室学术委员会委员 / Member, Broad Committee of the Key Laboratory of Chinese Herbal Medicine Resource and Traditional Chinese Medicine Compound Prescriptions, Ministry of Education

5. 武汉市政协副主席 / Vice President, National Committee of the Chinese People's Political Consultative Conference of Wuhan

6. 民建湖北省委副主委 / Vice President, China National Democratic Construction Association of Hubei

7. 民建武汉市委主委 / President, China National Democratic Construction Association of Wuhan

研究方向 / Research Interests

1．酶与催化：既研究天然酶，又研究模拟酶，研究它们的结构与功能的关系、催化机理、分子改造/ Enzyme and Catalysis: Research nature enzyme, simulation enzyme and the relationship between structure and function, catalytic mechanism, and molecule design

2．金属螯合物（重点是博莱霉素、阿霉素等抗癌抗生素以及金属卟啉、酞菁、菲咯啉等）与自由基：这些金属螯合物与氧自由基密切相关，研究它们的分子药理，模拟酶性质及自由基理论/ Metal Chelation and Free Radical: Research their molecular pharmacology, simulation enzyme character, and free radical principle

3．药学：重点研究抗病毒、抗菌、抗癌药物，包括中草药有效成分的发现、分离与表征，抗病毒基因工程疫苗的研制，药用酶的基因工程改造等/ Pharmacy: Research the antivirus, antibacterial and anticancer drugs, which includes discovering effective ingredient of Chinese traditional drugs, preparing gene engineering bacteria, and so on

近期代表性学术论文 / Selected Recent Publications

1. Handong Fan, Jing Liu, Wendan Ren, Zhongliang Zheng, Yuying Zhang, Xi Yang, Huaping Li, Xiaoyan Wang, Guolin Zou* (2008). PH Induces Thermal Unfolding of UTI: An Implication of Reversible and Irreversible Mechanism Based on the Analysis of Thermal Stability, Thermodynamic, Conformational Characterzation. J Fluoresc 18:305-317.

2. Yang He, Yiwei Wang, Lifei Tang, Hui Liu, Wei Chen, Zhongliang, Zheng, Guolin Zou* (2008).Binding of Puerarin to Human Serum Albumin: A Spectroscopic Analysis and Molecular Docking. J Fluoresc 18:433-442.

3. Xiwen Li, Guolin Zou* (2007). Exciton Coupling of Tetra (p-hydroxyphenyl) porphyrin Controlled by Substituents of Counterions in Triton X-100 Micellar Solution. J Phys Chem B 111(6):1502-1506.

4. Xiwen Li, Guolin Zou* (2007). Tuning J-Aggregation of Tetra (p-hydroxyphenyl) porphyrin by Headgroup of Ionic Surfactant in Acidic Nonionic Micellar Solution. J Phys Chem B 111(17): 4342-4348.

5. Yanbin Liu, Fan Wu, Guolin Zou* (2007). Electrophoresis mobility shift assay and biosensor used in studying the interaction between bleomycin A5 and DNA. Analytica Chimica Acta 599:310-314.

6. Jun-Chao Huang, De-Jia Li, Jie Hou, Jiang-Lan Yuan, Guolin Zou* (2007). A novel fluorescent method for determination of peroxynitrite using folic acid as a probe. Talanta 72(4): 1283-1287.

7. Zhong Lv, Yuying Zhang, Hui Liu, Jianglan Yuan, Zhongliang Zheng, Guolin Zou* (2007). Transport of a Cancer Chemopreventive Polyphenol, Resveratrol: Interaction with Serum Albumin and Hemoglobin. J Fluoresc 17:580-587.

8. Xian-Fei Xie, Xiao-Qiang Cai, Shun-Ying Zhu, Guolin Zou* (2007). Chemical composition and antimicrobial activity of essential oils of Chaenomeles speciosa from China. Food Chemistry 100:1312-1315.

9. Zhong-Liang Zheng, Mao-Qing Ye, Zhen-Yu Zuo, Zhi-Gang Liu, Keng-Chang Tai, Guolin Zou* (2006). Probing the importance of hydrogen bonds in the active site of the subtilisin nattokinase by site-directed mutagenesis and molecular dynamics simulation. Biochem J 395:509-515.

10. Hui-Hong Liu, Yong-Qing Wan, Guolin Zou* (2006). Direct electrochemistry and electrochemical catalysis of immobilized hemoglobin in an ethanol-water mixture. Anal Bioanal Chem 385(8): 1470-1476.

11. Zhong-Liang Zheng, Zhen-Yu Zuo, Zhi-Gang Liu, Keng-Chang Tsai, Ai-Fu Liu, Guolin Zou* (2005). Construction of a 3D model of nattokinase, a novel fibrinolytic enzyme from Bacillus natto a novel nucleophilic catalytic mechanism for nattokinase. J Mol Graphics Modell 23:373-380.

12. Jun Rong, Tai-Pin Cheng, Xiao-Na Liu, Tao-Zhen Jiang, Hong Gu, Guolin Zou* (2005). Development of recombinant VP2 vaccine for the prevention of infectious bursal disease of chickens. Vaccine 23(40): 4844-4851.

联系方式 / Contact Information
电话 / Tel: 86-27-87645674 (Lab)
电子邮箱 / E-mail: zouguolin@whu.edu.cn