学习经历 / Education
1990－1994年 美国北卡大学 分子生物学 博士/ Ph.D. in Biochemistry, University of beika, USA.
1979－1981年 武汉大学 病毒学 硕士 / M.S. in Virology, Wuhan University, China.
1965－1970年 武汉大学 微生物学 学士 / B.S. in Microbiology, Wuhan University, China
工作经历 / Work Experience
2005-至今：病毒学国家重点实验室，教授/Professor, State Key Laboratory of Virology, China.
1994-至今：武汉大学，教授 / Professor, Wuhan University, Wuhan, China.
1985-1986：加拿大Queews大学，访问学者 /Queens University of canada,
1979-1990：武汉大学，讲师 / Lecture, Wuhan University, China
学术兼职 / Committee and Broad Memberships
1. 国家自然科学基金委员会学科评审组专家 / Member, Grant Review Committee of National Natural Science Foundation of China
2. 国家科学技术奖评审专家 / Member, Committee of National Awards for Science and Technology, China
3. 湖北省生化分子生物学学会副理事长 /vice President, Hubei Society for Bioche.molecular biol
研究方向 / Research Interests
用分子生物学，细胞生物学，免疫学，研究病毒基因结构、功能、蛋白质性质和功能、病毒感染与机体免疫反应、病毒病诊断、预防疫苗、基因工程医药等。/Using molecular biology ,cell biology and Immunology technices to study the viral genes and proteins functions ,viral infection and host immunological responses ,viral infection diagnosis ,vaccines and medicine.
近期代表性学术论文 / Selected Recent Publications
1. Khalid Amine Timani , Li Ye, Linbai Ye* et al,Cloning, sequencing, expression, and purification of SARS-associated coronavirus nucleocapsid protein for serodiagnosis of SARS. Journal of Clinical Virology. 30(4), August, 2004, pp. 309-312.
2. Li Ye, K.A.Timani, Linbai Ye* et al., Two cis-acting elements of HCV negative-strand RNA for positive-strand RNA synthesis in vitro. Acta virologica. 2005, 49: 83-90.
3. Lingbao Kong, Linbai Ye*, Li Ye et al., Establishment of stable HeLa cell line to express enzymatically active hepatitis C virus RNA polymerase Archives of Virology.2005
4. Xiao-Jun Yang Lin-Bai Ye ? et al HCV NS2 protein inhibits cell proliferation and induces cell cycle arrest in the S-phase in mammalian cells through down-regulation of cyclin A expression Virus Research 121(2006)134-143
5. L. B. Kong1, L. B. Ye1, L. Ye* et al Establishment of stable HeLa cell line to express enzymatically active hepatitis C virus RNA polymerase. Arch Virol 2006，151(2):361-367
6. Zhong-Hua Xiang, Lin-Bai Ye et al Purification and application of bacterially expressed chimeric protein E1E2 of hepatitis C virus. Protein Expression and Purification2006, (49):95－101
7. Zeng L, Ye L, Lu Y. et al HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1. J Gene Med 2006 Jan;8(1):18-28.
8. Zeng, L; Yang, S; Wu, C; Ye, L; Lu, Y et al Effective transduction of primary mouse blood- and bone marrow-derived monocytes/macrophages by HIV-based defective lentiviral vectors Journal of Virological Methods J. Virol. Methods Vol. 134, no. 1-2, pp. 66-73. Jun 2006.
9． Zheng H, Ye L, Fang X, Li B, Wang Y, Xiang X, Kong L, Wang W, Zeng Y, Wu Z, She Y, Zhou X. Torque Teno Virus (SANBAN isolate) ORF2 Protein Suppresses the NF-{kappa}B Pathways via Interaction with I{kappa}B Kinases. J Virol.; 2007 NOV；P.1197-11924
10． Kong L, Li S, Han X, Xiang Z, Fang X, Li B, Wang W, Zhong H, Gao J, Ye L.
Inhibition of HCV RNA-dependent RNA polymerase activity by aqueous extract from Fructus Ligustri Lucidi. Virus Res. 2007 128(1-2):9-17
11．Baozong Li, Bo Gao, Linbai Ye*, Xue Han, Wei Wang, Lingbao Kong, Xiaonan Fang,Yingchun Zeng, Hong Zheng, Shanshan Li, Zhenghui Wu, Li Ye. Hepatitis B virus X protein (HBx) activates ATF6 and IRE1-XBP1 pathways of unfolded protein response Virus Research 124 (2007) 44–49
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