学习经历 / Education

1997-2000：四川大学 有机化学 博士 / Ph.D. in Organic Chemistry, Sichuan University, China.

1994-1997：四川大学 有机化学 硕士 / M.S. in Organic Chemistry, Sichuan University, China.

1990-1994：延安大学 化学 学士 / B.S. in Chemistry, Yan’an University, China.


工作经历 / Work Experience

2007-至今：武汉大学药学院，教授、博士生导师 / Professor, College of Pharmacy, Wuhan University.

2003-2007：美国伊利诺伊大学香槟分校 博士后研究员 / Postdoctoral Associate, University of Illinois at Urbana-Champaign, USA.

2001-2003：加拿大渥太华大学 博士后 / Postdoctoral Fellow, University of Ottawa, Canada
.
2000-2001：香港大学 研究助理 / Research Associate, The University of Hong Kong, China.


学术兼职 / Committee and Broad Memberships

1. 湖北省药学会理事 / Member, Hubei Pharmaceutical Association.

2. 湖北省药学会药物化学专业委员会常务理事/ Broad Member, Division of Medicinal Chemistry of Hubei Pharmaceutical Association.

研究方向 / Research Interests

1. 具有潜在抗病毒活性（抗 HIV 等）的杂环小分子化合物 和 甾体类衍生物的新法合成及性能研究 / New methodologies for the synthesis of small heterocycles and steroid derivatives with potential antivirus (including anti-HIV) activity.

近期代表性学术论文 / Selected Recent Publications

1. Nettles KW, Bruning JB, Gil G, Nowak J, Sharma SK, Hahm JB, Kulp K, Hochberg RB, Zhou HB, Katzenellenbogen JA, Katzenellenbogen BS, Kim Y, Joachmiak A, Greene GG (2008). NF-KB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses. Nature Chemical Biology 4(4):241-247.

2. Zhou HB, Nettles KW, Bruning JB, Kim Y, Joachimiak A, Sharma S,Carlson KE, Stossi F, Katzenellenbogen BS, Greene GL, Katzenellenbogen JA (2007). Elemental isomerism: A boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands. Chemistry Biology 14(6):659-669.

3. Zhou HB, Sheng S, Compton DR, Kim Y, Joachimiak A, Sharma S, Carlson KE, Katzenellenbogen BS, Nettles KW, Greene GL, Katzenellenbogen JA (2007). Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains. J Med Chem 50(2):399-403.

4. Zhou HB, Collins ML, Gunther JR, Comninos JS, Katzenellenbogen JA (2007). Bicyclo[2.2.2]octanes: close structural mimics of the nuclear receptor-binding motif of steroid receptor coactivators. Bioorg Med Chem Lett 17(15):4118-4122.

5. Zhou HB, Comninos JS, Stossi F, Katzenellenbogen BS, Katzenellenbogen JA (2005). Synthesis and evaluation of estrogen receptor ligands with bridged oxabicyclic cores containing a diarylethylene motif: Estrogen antagonists of unusual structure. J Med Chem 48(23):7261-7274.

6. Zhang J, Liang JL, Sun XR, Zhou HB, Zhu NY, Zhou ZY, Chan PWH, Che CM (2005). Chiral osmium complexes with sterically bulky Schiff-base ligands. Crystal structures of Os(IV) derivatives and the reactivity and catalytic cyclopropanation of alkenes with EDA. Inorganic Chemistry 44(11):3942-3954.

7. Zhou HB, Dong C, Alper H (2004). Novel rhodium-catalyzed reaction of thiazolidine derivatives with carbodiimides. Chem-Eur J 10(23):6058-6065.

8. Zhou HB, Alper H (2004). Regioselective and enantioselective synthesis of seven-membered ring cyclic arylguanidine and urea derivatives. Tetrahedron 60(1):73-79.

9. Zhou HB, Alper H (2003). Synthesis of seven-membered ring diazepin-2-ones via palladium-catalyzed highly regioselective cyclization of 2-vinylpyrrolidines with arylisocyanates. J Org Chem 68(9):3439-3445.

10. Zhang JL, Zhou HB, Huang JS, Che CM (2002). Dendritic ruthenium porphyrins: A new class of highly selective catalysts for alkene epoxidation and Cyclopropanation. Chem-Eur J 8(7):1554-1562.

11. Zhou HB, Lu SM, Xie RG, Chan ASC, Yang TK (2001). Chiral monoamidoalcohols and diamidoalcohols of squaric acid: New catalysts for the asymmetric reduction of ketones by borane. Tetrahedron Lett 42(6):1107-1110.

12. Zhou HB, Zhang J, Lu SM, Xie RG, Zhou ZY, Choi MCK, Chan ASC, Yang TK (2001). Design, synthesis and structure of new chiral squaric acid monoaminoalcohols and diamioalcohols and their use as catalysts in asymmetric reduction of ketones and diketones. Tetrahedron 57(45):9325-9333.