武汉大学，教授、博士生导师 / Professor, Wuhan University.

国家杰出青年基金获得者（2004年）

教育部跨世纪优秀人才培养计划获得者（2002年）


学习经历 / Education

1998-2001：美国马里兰大学化学与生物化学系，博士后/ Research Associate in Chemistry, University of Maryland, College Park, USA.

1996-1998： 美国弗及利亚大学化学系 博士后 / Research Associate in Chemistry, University of Virginia, USA.

1993-1996：香港中文大学化学系，化学 博士 / Ph.D. in Chemistry, The Chinese University of Hong Kong

1986-1989：武汉大学 化学 硕士 / M.S. in Chemistry, Wuhan University, China.

1972-1986：武汉大学化学 学士 / B.S. in Chemistry, Wuhan University, China.


工作经历 / Work Experience

2001-至今：.武汉大学，教授 / Professor, Wuhan University, Wuhan, China.

1989-1993：武汉大学，讲师 / Lecturer, Wuhan University, China


学术兼职 / Committee and Broad Memberships

1. 国家自然科学基金委员会学科评审组专家 / Member, Grant Review Committee of National Natural Science Foundation of China


研究方向 / Research Interests

1． 以核酸为靶标的药物设计、合成及活性研究 / Design, synthesis and bioactivity of drugs targeting nucleic acid.

2． 核酸端粒酶抑制剂的设计、合成及活性研究 / Design, synthesis and bioactivity of drugs inhibiting telomeras.


近期代表性学术论文 / Selected Recent Publications

1. Baoping Zhai, Li Shuai, Li Yang, Xiaocheng Weng, Lin Wu, Shaoru Wang, Tian Tian, Xiaojun Wu, Xiang Zhou*, Congyi Zheng, “Octa-substituted Anionic Porphyrins: Topoisomerase I Inhibition and Tumor Cell Apoptosis Induction”, Bioconjugate Chem., 2008, in press.

2. Zhibin Song, Xiaocheng Weng, Liwei Weng, Jing Huang, Xiaolin Wang, Minghui Bai, Yangyang Zhou, Guangfu Yang, and Xiang Zhou*, “Synthesis and Oxidation-Induced DNA Cross-linking Capabilities of Bis-catechol Quaternary Ammonium Derivatives”, Chem. Eur. J., 2008, in press.

3. Xiaocheng Weng, Lige Ren, Liwei Weng, Jing Huang, Shugao Zhu, Xiang Zhou,* Linhong Weng, “Synthesis and Biological Studies of New Inducible DNA Cross-linking Agents”, Angew. Chem. Int. Ed. 2007, 46: 8020

4. Boqiao Fu, Jing Huang, Lige Ren, Xiaocheng Weng, Yangyang Zhou, Yuhao Du, Xiaojun Wu, Xiang Zhou*, Guangfu Yang, “Cationic Corrole Derivatives: A New Family of G-quadruplex Inducing and Stabilising Ligands”, Chem. Commun. 2007, 3264.

5. Lige Ren, Anming Zhang, Jing Huang, Ping Wang, Xiaocheng Weng, Feng Liang, Zheng Tan, Xiang Zhou*, “Quaternary Ammonium Zinc Phthalocyanine: Inhibiting Telomerase by Stabilizing G-quadruplex and Inducing G-quadruplex Structure Transition and Formation”, ChemBioChem, 2007, 8:775.

6. Yang Song, Tian Tian, Ping Wang, Hanping He, Wulue Liu, Xiang Zhou,* Xiaoping Cao,Xiao-Lian Zhang, Fang Zheng, Xin Zhou*, “Phenol Quaternary Ammonium Derivatives: Charge and Linker Effect on Their DNA Photo-inducible Cross-linking Abilities”, Org. Biomol. Chem., 2006, 4:, 3358.

7. Ping Wang, Lige Ren, Hanping He, Feng Liang, Xiang Zhou,* Zheng Tan*, “A Phenol Quaternary Ammonium Porphyrin as A Potent Telomerase Inhibitor by Selective Interaction with Quadruplex DNA”, ChemBioChem, 2006, 7:1155.

8. Ping Wang, Yang Song, Lixia Zhang, Hanping He, Xiang Zhou*, “Quinone Methide Derivatives: Important Intermediates to DNA Alkylating and DNA Cross-linking Actions”, Curr. Med. Chem. 2005, 12:2893.

9. Xiao-Lian Zhang*, Jia Tao Ye, Peng Xie, Xiang Zhou*, Jianguo Wu, “Effect of N-pentafluorobenzyl-1-deoxynoirimycin on cytokines production”, Bioorg. Med. Chem. Lett., 2004, 14:3789.

10. Ping Wang, Renpeng Liu, Xiaojun Wu, Hongjuan Ma, Xiaoping Cao, Ping Zhou, Jiangye Zhang, Xiaocheng Weng, Xiao-Lian, Zhang, Jun Qi, Xiang Zhou*, Linhong Weng, “A Potent, Water-soluble and Photoinducible DNA Cross-linking Agent”, J. Am. Chem. Soc., 2003,125:, 1116.