中国科学院武汉病毒研究所所长、研究员、博导， Director, Wuhan Institute of Virology Chinese Academy of Sciences.

病毒学国家重点实验室副主任， Deputy Director, State Key Laboratory of Virology.

中国科学院 “ 百人计划 ” 入选者，国家 “ 杰出青年基金 ” 获得者。
Awardee of the Hundred Talents Project from CAS,
Awardee of the National Outstanding Young Scientist grant.


学习经历 / Education

1996-2001 ：荷兰 Wageningen 大学 病毒学 博士 / Ph.D. in Virology, Wageningen University ( Wageningen Agricultural University ), the Netherlands ;

1986-1988 ：河南工业大学 ( 原郑州粮食工业学院 ) 研究生班 / MSc course, (Major in Biochemistry), Henan University of Technology, Zhengzhou , China

1982-1986 ：华中师范大学 生物学 学士 / B.S. in Biology, Central China Normal University , China .


工作经历 / Work Experience

2008- 至今：中国科学院武汉病毒研究所，所长 / Director, Wuhan Institute of Virology, Chinese Academy of Sciences,

2004-2008 ：中国科学院武汉病毒研究所，副所长 / Deputy Director, Wuhan Institute of Virology, Chinese Academy of Sciences,

2000- 至今：中国科学院武汉病毒研究所，研究员 / Professor, Wuhan Institute of Virology, Chinese Academy of Sciences,

1997-2000 ：中国科学院武汉病毒研究所，副研究员 / Associate professor, Wuhan Institute of Virology, Chinese Academy of Sciences,

1992-1997 ：中国科学院武汉病毒研究所，助理研究员 / Assistant professor ， Wuhan Institute of Virology, Chinese Academy of Sciences,

1988-1992, 中国科学院武汉病毒研究所，实习研究员 / Research assistant, Wuhan Institute of Virology, Chinese Academy of Sciences .

1996-2000 荷兰农业大学，访问学者 /Visiting scientist; Department of Virology, Wageningen Agricultural University ， the Netherlands,

2002 美国加州大学伯克利分校，访问学者 / Visiting scientist, Department of Plant and Microbial Biology, University of California, Berkeley,USA

2006 德国 Essen 医学院病毒研究所 , 访问学者 / Visiting scientist, Institute of Virology, University Hospital Essen, Essen, German Institute of Virology, University Hospital Essen, Essen, German Institute of Virology, University Hospital Essen, Essen, German Institute of Virology, University Hospital Essen, Essen, German


学术兼职 / Committee and Broad Memberships

1. 中国微生物学会医学微生物与免疫学专业委员会委员 / Broad Member, Division of Medical Microbiology and Immunology of Chinese Society for Microbiology

2. 湖北生物工程学会常务理事 , 副理事长 / Vice Chairman, Broad Member, Hubei Society for Biotechnology

3. 湖北省微生物学会常务理事 / Broad Member, Hubei Society for Microbiology.

4. 《中国病毒学》主编 / Chief editor, Virologica Sinica


研究方向 / Research Interests

针对危害人类健康的重要病毒病如乙型肝炎和丙型肝炎开展型乙肝炎病毒 (HBV) 和丙型肝炎病毒 (HCV) 的分子生物学和病毒与宿主 ( 细胞 ) 相互作用等方面的研究，揭示病毒致病的分子机理，研制基因工程疫苗，探索新的诊断及治疗方法。同时构建具有自主知识产权的杆状病毒载体系统用于重要疾病的基因治疗。/Our research group focuses on several different aspects of molecular virology, viral pathogenesis and vaccine development. The group studies hepatitis viruses (such as HBV and HCV) and baculovirus. Currently, the research projects are on the genetic diversity and the genetic bases of clinical outcome of hepatitis virus's infection. Several systems are being utilized in the laboratory to investigate the interaction between the virus and its host. Our laboratory is also interested in the investigation of immunotherapeutic and prophylactic vaccines, and to that end we are exploring opportunities to develop and use baculovirus vectors for gene expression and gene delivery applications in vitro and in vivo.


近期代表性学术论文 /Selected Recent Publications

1 Xiangjie Yao, Qingxia Han, Jianhua Song, Changyong Liang, Takaji Wakita, Rongge Yang, Xinwen Chen .2008 Baculovirus mediated production of infectious Hepatitis C virus in human hepatoma cells stably expressing T7 RNA polymerase Molecular Biotechnology, DOI 10.1007/s12033-008-9075-2

2 Qian Wang, Yun Wang, Changyong Liang, Jianhua Song, Xinwen Chen，2008, Identification of a hydrophibic domain of HA2 essential to morphogenesis of Helicoverpa armigera nucleopolyhedrovirus.Journal of Virology 82（8）:4072－4081 (doi:10.1128/ JVI.02319-07 ）

3 Yun Wang, Qian Wang, Changyong Liang, Jianhua Song, Ni Li, Hui Shi, Xinwen Chen， 2008 ， BV/ODV-C42 involves in baculovirus morphogenesis via mediating the nuclear entry of P78/83. Journal of Virology 82: 4554-4561 (doi:10.1128/JVI.02510-07)

4 Fei Deng, Ranran Wang, Minggang Fang, Yue Jiang, Xushi Xu, Hanzhong Wang, Xinwen Chen , Basil M. Arif, Lin Guo, Hualin Wang, and Zhihong Hu 2007 Proteocs analysis of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus identified two new occlusion-derived virus-associated proteins, HA44 and HA100 Journal of Virology 81(17):9377-9385

5 Yufeng Zhang, Jianhua Song, Bin Shi , Yining Wang, Xiaohui Chen , Cui Huang, Xuecao Yang, Dongxuan Xu, Xiangrong Cheng, Xinwen Chen 2007 Combination of scaffold and adenovirus vectors expressing bone morphoge2007 Nov;netic protein-7 for alveolar bone regeneration at dental implant defects Biomaterials 28(31):4635-42

6 Ying Peng , Jianhua Song, Jianxin Lu, Xinwen Chen , 2007 The histone deacetylase inhibitor Sodium Butyrate inhibit baculovirus mediated the transgene expression in Sf9 cells. Journal of Biotechnology 131(2): 180-187

7 Qian Wang, Changyong Liang, Jianhua Song , Xinwen Chen. 2007 . HA2 from the Helicoverpa armigera nucleopolyhedrovirus: a WASP-related protein that activates Arp2/3-induced actin filament formation. Virus Res. 127(1):81-7.

8 Xiang Li, Jianhua Song, Ting Jiang, Changyong Liang, Xinwen Chen. 2007 . Autographa californica multiple nucleopolyhedrovirus pif-3 N-terminal hydrophobic sequence is essential for oral infection, Archives of Virology 152(10):1851-1858