中国科学院武汉病毒研究所，研究员 / Professor, Wuhan Institute of Virology, Chinese Academy of Sciences

学习经历 / Education

1999-2002 ： 中国科学院研究生院 / 中国科学院水生生物研究所 遗传学 / 分子病毒学 博士 / Ph.D., Genetics/Molecular Virology, Graduate School of Chinese Academy of Sciences; Institute of Hydrobiology, Chinese Academy of Sciences,

1978-1982 ：华中农业大学 学士 / B.S. Huazhong Agricultural University.

工作经历 / Work Experiences

2007- 至今： 研究员，中科院武汉病毒研究所，分子病毒研究室，水生病毒学科组负责人 /Professor, Aquatic viruses research group leader , Laboratory of Molecular Virology ,Wuhan Institute of Virology, CAS .

1995-2006 ：副研究员 , 中科院武汉病毒研究所，分子病毒研究室 / Laboratory of Molecular Virology ,Wuhan Institute of Virology, CAS .

1997-1998 ：访问学者， 美国匹滋堡大学医学院分子遗传与生化系 / visiting researcher, Department of Molecular Genetics and Biochemistry, University of Pittsburgh, School of Medicine, Pittsburgh, USA

1982 – 1995 ：助理研究员 , 中科院武汉病毒研究所工作，分子病毒研究室 /research assistant, Laboratory of Molecular Virology ,Wuhan Institute of Virology, CAS .

主要研究方向 / Major Research Interests

主要研究方向是以水生生物病毒－草鱼呼肠孤病毒(Grass Carp Reovirus,GCRV)为研究模型，进行包括人类、哺乳动物、水生动物、植物、昆虫的dsRNA病毒的基因组与衣壳蛋白的结构与功能比较研究，探讨dsRNA病毒内源性转录复制机理以及病毒外衣壳蛋白在侵染过程中与宿主细胞的相互作用。
Viruses with dsRNA genomes in the Reoviridae family infect a wide range of hosts, including plants, insects, fishes, mammalians and humans. The major purpose of this group is to investigate the molecular biology characteristics and structural basis of the viruses isolated from aquatic animals, primarily Grass Carp Reovurs(GCRV). The current research interests include the fundamental aspects of the transcription mechanisms involved within icosahedral particles, virus-cell interaction, virus particle assembly, and viral pathogenesis by using GCRV as model.

近期代表性学术论文 / Selected Recent Publications

1． Cheng Lingpeng, Qin Fang*, Sanket Shah, Ivo C. Atanasov and Z. Hong Zhou*, Subnanometer-resolution Three-Dimensional Structures of the Grass Carp Reovirus Core and Virion, JMB,2008.

2． Zhang Lan-lan, Shen JY , Lei CF, Li XM, Fang Q* (2008). The High Level Expression of Grass carp reovirus VP7 Protein in Prokaryotic Cells，Virologica Sinica ,23(1):51-56.

3． Fang Q*., Seng E.K. , Ding Q.Q., Zhang,L.L. (2008). Characterization of Infectious Particles of Grass Carp Reovirus by Treatment with Proteases. Arch of Virol,153:675-682.

4． Fang Q*, Seng Eng Khuan, Zhang Lanlan, 2007, Construction and Co-expression of Grass Carp Reovirus VP6 Protein and Enhanced Green Fluorescence Protein in the Insect Cells, Virologica Sinica,22(5):397-404.

5． Fang Q*., Sanket Shah, Y.Y. Liang, Z. H. Zhou*., 3D Reconstruction and Capsid Protein Characterization of Grass Carp Reovirus ,Sciences in China series C(2005),48(6):593-600.

6． Seng E. K, Q. Fang,Y. M. Sin, et al., Molecular characterization of a major outer capsid protein encoded by the Threadfin aquareovirus (TFV) gene segment 10 (S10) (2005). Arch Virol, 150: 2021–2036.

7． Seng, E. K, Q. Fang, Y. M. Sin.et al. (2005). Molecular Cloning, DNA Sequence Analysis, and Expression of cDNA Sequence of RNA Genomic Segment 6 (S6) that Encodes a Viral Outer Capsid Protein of Threadfin Aquareovirus (TFV),Virus Gene, 30(2):209-221.

8． Attoui, H. , Q. Fang, F. Mohd Jaafar, J. F. Cantaloube, P. Biagini, P. de Micco and X. de Lamballerie. Common Evolutionary Origin of Aquareoviruses and Orthoreoviruses Revealed by Genome Characterization of Golden Shiner Reovirus, Grass Carp Reovirus, Striped Bass Reovirus and Golden ide Reovirus (genus Aquareovirus, family Reoviridae)( 2002). J Gen Virol , 83:1941-1951.