学习经历 / Education
1995-1998：美国华盛顿大学 博士后 / Postdoctoral fellow, University of Washington, USA.
1993-1995：美国弗吉利亚大学 博士后 / Postdoctoral fellow, University of Virginia, USA.
1987-1992：美国内华达大学 生物化学 博士 / Ph.D. in Biochemistry, University of Nevada, USA.
1983-1986：武汉大学 生物学 硕士 / M.S. in Biology, Wuhan University, China.
1979-1988：武汉大学 生物学 学士 / B.S. in Biology, Wuhan University, China.
工作经历 / Work Experience
2007-至今：教育部“长江学者奖励计划”， 生化及分子生物学特聘教授 / Chair Professor of Biochemistry and Molecular Biology, Cheung Kong Scholars Program, Ministry of Education, China.
2005-至今：武汉大学生科院，教授 / Professor, College of Life Sciences, Wuhan University.
1998-2005: Immunex公司/Amgen公司， 美国西雅图， 历任初级科学家、科学家、高级科学家/Associate Scientist, Scientist, Senior Scientist, Immunex /Amgen Corporation, Seattle, USA
研究方向 / Research Interests
本实验室以蛋白质组学及生物质谱学为主要研究方法，重点研究感染与天然免疫过程中的蛋白组变化以及蛋白质信号传导通路。
Using proteomics and biological mass spectrometry as the main research methodologies, our primary research interests are to study proteome changes and signal transduction networking associated with infection and innate immunity.
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近期代表性学术论文 / Selected Recent Publications
1. Lin, B., Li, T., Zhao, Y., Huang, F.K., Guo, L*., Feng, Y.Q*. (2008) Preparation of a TiO(2) nanoparticle-deposited capillary column by liquid phase deposition and its application in phosphopeptide analysis. J Chromatogr A. 2008 23;1192(1):95-102. Epub 2008 Mar 20.
2. Deng, F., Wang, R., Fang, M., Jiang, Y., Xu, S., Wang, H., Chen, X., Arif, B. M., Guo, L., Wang, H., Hu, Z., (2007) Proteomics analysis of HearNPV identified two new ODV associated proteins, HA44 and HA100. J. of Virology 81:9377-85.
3. Guo, L., Kozlosky, C. J., Ericsson, L. H., Daniel, T. O., Cerretti, D. P., and Johnson, R. S. (2003). Studies of ligand-induced site-specific phosphorylation of epidermal growth factor receptor. Journal of the American Society for Mass Spectrometry 14:1022-1031.
4. Shen, M., Guo, L., Wallace, A., Fitzner, J., Eisenman, J., Jacobson, E., and Johnson, R. S. (2003). Isolation and Isotope Labeling of Cysteine- and Methionine-containing Tryptic Peptides: Application to the Study of Cell Surface Proteolysis. Mol Cell Proteomics 2:315-324.
5. Black, R. A., Doedens, J. R., Mahimkar, R., Johnson, R., Guo, L., Wallace, A., Virca, D., Eisenman, J., Slack, J., Castner, B., et al. (2003). Substrate specificity and inducibility of TACE (tumour necrosis factor alpha-converting enzyme) revisited: the Ala-Val preference, and induced intrinsic activity. Biochemical Society Symposia, 70:39-52.
6. Guo, L., Eisenman, J. R., Mahimkar, R. M., Peschon, J. J., Paxton, R. J., Black, R. A., and Johnson, R. S. (2002). A proteomic approach for the identification of cell-surface proteins shed by metalloproteases. Molecular & Cellular Proteomics 1:30-36.
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