病毒学国家重点实验室 / State Key Laboratory of Virology.

中国科学院武汉病毒研究所病毒RNA结构与功能关系学科组，学科组长 /Research Group Leader, Viral RNA Structure/Function Research Group, Wuhan Institute of Virology, Chinese Academy of Sciences

研究员、博士生导师 / Research Professor

学习经历 / Education

2000-2003 德国弗莱堡大学医院 分子病毒学 博士后 / Postdoctoral Associate in Virology, University Hospital of Freiburg, Freiburg, Germany.

1999-2000：德国杜塞尔多夫大学 分子病毒学 博士后 / Postdoctoral Associate in Virology, University of Duesseldorf, Duesseldorf, Germany.

1995-1999：德国杜塞尔多夫大学 病毒学 博士 / Ph.D. in Virology, University of Duesseldorf, Germany.

1985-1988：中国科学院武汉病毒研究所 病毒学 硕士 / M.S. in Virology, WIV, CAS, China.

1981-1985：武汉大学 微生物学 学士 / B.S. in Microbiology, Wuhan University, China.


工作经历 / Work Experience

2008-至今：中国科学院武汉病毒研究所病毒RNA结构与功能关系学科组 组长/ Research Group Leader, Viral RNA Structure/Function Research Group, WIV, CAS, China

2006-2008：德国雷根斯堡大学，助理教授 / Assistant Professor, University of Regensburg , Regensburg, Germany

2003-2006：德国雷根斯堡大学医院，高级科学家，课题组长 / Senior Scientist, Research
Group Leader, University Hospital of Regensburg, Regensburg, Germany

1990-1995：中国科学院武汉病毒研究所，助理研究员 / Research Associate, WIV, CAS, China

1988-1990：中国科学院武汉病毒研究所，研究实习员 / Research Assistant, WIV, CAS, China


学术兼职 / Committee and Broad Memberships

1. 德国弗理德里希?艾伯特基金会生命科学奖学金生导师 / Advisor for Scholarship Winners of Life Sciences, Friedrich-Ebert-Foundation, Germany

2. 中国留德医学和生命科学学会理事, 常务副理事长/ Broad Member and Vice President, Association of Chinese Scholars in Medicine and Life Sciences in Germany


研究方向 / Research Interests

1． 探索肝炎病毒、类病毒RNA结构与功能相互关系在复制过程中的意义。/Our interest focuses on hepatitis viruses and viroids. Exploring the relationship between viral RNA structure and function and its implication for viral replication.

2． 为设计新颖的抗病毒药物靶标提供理论依据/ discovery of interacting target sites is valuable for designing novel antiviral drugs.

近期代表性学术论文 / Selected Recent Publications

1. Hu K.* and Yao Y. 2008 “Advances in application of three-dimensional cell culture” Journal of Medicine Molekular Biology 5(2):185-188

2. Hu K. et al. 2007 “Chemically defined medium determines the differential potency of renal stem cells” Biotechnology Journal 2(8), 992-995

3. Minuth WW, Denk L and Hu K.* 2007 “Kontrolliertes Environment für die Entwicklung von Stammzellen zu renalen Tubuli“ Regenerativ Medizin 2(1):22-27

4. Minuth WW., Denk L. and Hu K. 2007 “The role of polyester interstitium and aldosterone during structural development of renal tubules in serum-free medium” Biomaterials 28(30):, 4418-4428

5. Minuth WW, Denk L, Hu K.* et al. 2007 “The tubulogenic effect of aldosterone is attributed to intact binding and intracellular response of the mineralocorticoid receptor” Central European Journal of Biology 2(3): 307-325

6. Minuth WW and Hu K* 2007 “Kontrolliertes Environment für Stammzellen – Generierung renaler Tubuli in chemisch definiertem Kulturmedium“ Bioforum 4:28-29

7. Heber S., Denk L., Hu K., and Minuth WW. 2007 “Modulating the development of renal tubules growing in serum-free culture medium at an artificial interstitium” Tissue Engineering 13(2):, 281-292

8. Nadine K., Oliver B., Ashermann K., Hu KH. et al. 2006 “Transcription of potato spindle tuber viroid by RNA polymerase II starts in the left terminal loop” Virology 347(2):392-404

9. Hu K. et al. 2005 "Characterization of the human zinc finger protein 267 promoter: Essential role of nuclear factor Y" Biochimica et Biophysica Acta 1729:14-23

10. Schnabl B., Hu K., Mühlbauer M. und Sch?lmerich J. 2005 "Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10" Biochemical and Biophysical Research Communications 335:87-96.

11. Hu K., Beck J. and Nassal M. 2004 "SELEX-derived aptamers of the duck hepatitis B virus RNA encapsidation signal distinguish critical and non-critical residues for productive initiation of reverse transcription" Nucleic Acids Research 32(14):4377-4389

12. Fels A., Hu K. and Riesner D. 2001 "Transcription of potato spindle tuber viroid by RNA polymerase II starts predominatly at two specific sites" Nucleic Acids Research 29(22):4589-4597