中国科学院武汉病毒所，教授、博士生导师 / Professor, Wuhan Institute of Virology, Chinese Academy of Sciences

病毒学国家重点实验室人畜共患病学科组组长/Group leader, Zoonotic diseases research group, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, China.

学习经历 / Education

2002-2004 中国科学院武汉病毒所,博士/PhD. in Virology, Wuhan Institute of Virology, Chinese Academy of Sciences.

1999-2000 荷兰Wageningen大学，访问学者/Visiting Scholar, Wageningen University, Netherland.

1993-1994: 瑞典国家兽医研究,访问学者/Visiting Scholar, National Institute of Veterinary, Sweden

1976-1980: 武汉大学, 病毒学，学士/B.S. in Virology, Wuhan University, China.


工作经历 / Work Experience

2003-至今: 中国科学院武汉病毒所人畜共患病学科组，研究员Professor , Group of Zoonotic disease, State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, China.

1993-2002: 中国科学院武汉病毒所人畜共患病学科组，副研究员/Associate Professor, Group of Zoonotic disease, Wuhan Institute of Virology, Chinese Academy of Sciences, China.

1985-1992: 中国科学院武汉病毒所动物病毒室，助理研究员/Research Associate, Laboratory of animal Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, China.

1980-1984: 中国科学院武汉病毒所动物病毒室，研究实习员/Research Assistant, Laboratory of animal Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, China.


学术兼职 / Committee and Broad Memberships

1. 湖北省遗传学会，理事/Broad Member, Hubei Association for genetics.

2. 中国科学院武汉病毒所学术委员会委员/Broad Member, Academic Committee, Wuhan Institute of virology, Chinese Academy of Sciences.

3. 中国科学院武汉病毒所学位委员会委员/ Broad Member, Academic Degree Committee, Wuhan Institute of virology, Chinese Academy of Sciences.


研究方向 / Research Interests

以人畜共患病毒性疾病为主要研究方向，通过对几种重要的人畜共患病的研究，揭示这些重要的人畜共患病毒的分子进化和分子流行病学规律；病毒感染与宿主之间的相互关系；病毒的致病和跨种属传播的分子机理，同时开展新生病毒的鉴定以及相关疫苗和诊断试剂的研制和开发。
The main research fields include: the molecular epidemiology and evolution of zoonotic viruses; the molecular mechanisms of zoonotic virus transmission and infection from animal to human; the interaction between viral infection and host immune system; the identification of emerging infectious pathogens as well as development of diagnostic methods and novel vaccines.

近期代表性学术论文 / Selected Recent Publications

1. Bingke Bai, Qinxue Hu, Hui Hu, Peng Zhou, Zhengli Shi, Jin Meng, Baojing Lu, Yi Huang, Panyong Mao, Hanzhong Wang*. Virus-Like Particles of SARS-Like Coronavirus Formed by Membrane Proteins from Different Origins Demonstrate Stimulating Activity in Human Dendritic Cells. PLoS ONE , July 2008 , Volume, Issue 7, e2685.

2. Bingke Bai, Xinya Lu, Jin Meng, Qinxue Hu, Panyong Mao, Baojing Lu, Ze Chen, Zhiming Yuan, Hanzhong Wang*, Vaccination of Mice with Recombinant Baculovirus Expressing Spike or Nucleocapsid Protein of SARS-Like Coronavirus Generates Humoral and Cellular Immune Responses. Molecular Immunology.45 (2008) 868–875.

3. Xinya Lu, Yao Chen, Bingke Bai, Hui Hu, Ling Tao, Jihong Yang, Jianjun Chen, Ze Chen, Zhi hong Hu and Hanzhong Wang*. Immune responses against severe acute respiratory syndrome coronavirus induced by virus-like particles in mice. Immunology. 2007, 122 (4), 496–502.

4. Jihong Yang, Ting Wang, Yang Wang, Baojing Lu, Xuan Bai, Lei Zhang, Ming Wang, Hanzhong Wang*. Emergence of Human Rotavirus Group A Genotype G9 Strains in Wuhan, China. Emerging Infectious Diseases. 2007 October, 13(10): 1587-1589.

5. Yi Huang, Fei Deng, Zhihong Hu, Just M. Vlak , Hanzhong Wang*. Baculovirus-mediated gene silencing in insect cells using intracellularly produced long double-stranded RNA. Journal of Biotechnology. 2007, 128(2): 226-236.

6. Hui Hu, Xinya Lu , Ling Tao , Bingke Bai , Zhenfeng Zhang, Yao Chen, Fangliang Zheng , Jianjun Chen , Ze Chen, and Hanzhong Wang *. Specific immune responses induced by SARS-CoV spike DNA vaccine with or without interleukin-2 immunized via different immune routes in mice. Clinical and Vaccine Immunology. 2007, 14(7): 894-901.

7. Yanhong Si, Minggang Fang, Yi Huang, Fangliang Zheng, Ting Li, Zhihong Hu and Hanzhong Wang*. Construction and characterization of a Helicoverpa armigera nucleopolyhedrovirus bacterial artificial chromosome with deletion of ecdysteroid UDP-Glucosyltransferase gene. Biosci. Biotechnol. Biochem. 2007, 71(10): 2435-2441.

8. Li Liu, Qing Fang, Fei Deng, Hanzhong Wang, Christopher E. Yi, Lei Ba, Wenjie Yu, Richard D. Lin, Taisheng Li, Zhihong Hu,2 David D. Ho, Linqi Zhang and Zhiwei Chen* Natural Mutations in the Receptor Binding Domain of Spike Glycoprotein Determine the Reactivity of Cross-Neutralization between Palm Civet Coronavirus and Severe Acute Respiratory Syndrome Coronavirus. Journal of Virology, 2007, Vol.81, No. 9 p. 4694–4700.