学习经历 / Education
1981-1986：法国巴黎十一大学 生物化学 博士 / Ph.D. in Biochemistry, University de Paris 11, France.
1973-1977：中山大学 生物化学 学士 / B.S. in Biochemistry, Zhongshan University, China.
工作经历 / Work Experience
1995-至今：武汉大学，教授/Professor, Wuhan University, Wuhan, China
1993-1996：法国法国巴黎十一大学居里研究所，访问学者/ Visiting Scholar, Institute Curie, University de Paris 11, France
1993-1995：武汉大学，副教授/Associate Professor, Wuhan University, Wuhan, China
1991-1992：法国里昂一大学，访问学者/Visiting Scholar, University de Loyn I, France
1978-1981：武汉大学，讲师/Lecture, Wuhan University, Wuhan, China
学术兼职 / Committee and Broad Memberships
1. 国家自然科学基金委员会学科评审组专家 / Member, Grant Review Committee of National Natural Science Foundation of China
2. 国家科学技术奖评审专家 / Member, Committee of National Awards for Science and Technology, China
3. 病毒学国家重点实验室学术委员会委员 / Broad Committee of the State Key Laboratory of Virology, China
研究方向 / Research Interests
1． 蝎毒素组学和人早期胚胎发育生物学研究 / Focus on the toxinomics of scorpion and developmental biology of human early embryo.
2． 抗菌、抗病毒及抗肿瘤多肽药物研发/ Development of antibacterial, antiviral and anti-cancer peptide drugs.
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近期代表性学术论文 / Selected Recent Publications
1. Song Han, Hong Yi, Shi-Jin Yin, Zong-Yun Chen, Hui Liu, Zhi-Jian Cao, Ying-Liang Wu, Wen-Xin Li*. Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease. J.Bio.Chem. 2008-in press
2. Wang D, Guo MX, Hu HM, Zhao ZZ, Qiu HL, Shao HJ, Zhu CG, Xue L, Shi YB, Li WX*. Human T-cell leukemia virus type 1 oncoprotein Tax represses ZNF268 expression through the CREB/ATF pathway. J.Bio.Chem. 2008-in press
3. Yi H, Qiu S, Cao ZJ, Wu YL, Li WX*. Molecular basis of inhibitory peptide maurotoxin recognizing Kv1.2 channel explored by ZDOCK and molecular dynamic simulations. PROTEINS: Structure, Function, and Bioinformatics. 2008 80:744-54.
4. Liu WH, Liu ZC, Cao XB, Cao ZJ, Xue L, Zhu F, He XH, and Li WX*. Recombinant human foamy virus, a novel vector for neurological disorders gene therapy, drives production of GAD in cultured astrocytes. Mol.Ther. 2007, 15(10):1834-41.
5. Wu YL, Yi H, Cao ZJ, Li WX*. Conformation of Trimeric Envelope Glycoproteins: The CD4-dependent Membrane Fusion Mechanism of HIV-1. J Biomol.Struct.Dyn. 2007, 25(1):1-9.
6. Yi H, Cao ZJ, Yin SJ, Dai C, Wu YL, Li WX*. Interaction Simulation of hERG K+ Channel with its specific Bekm-1 peptide: Insights into the Selectivity of Molecular Recognition. J.Proteome.Res. 2007, 6(2): 611-20.
7. Guo MX, Wang D, Shao HJ, Qiu HL, Xue L, Zhao ZZ, Zhu CG, Shi YB, Li WX*. Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element. J.Bio.Chem. 2006, 281 (34): 24623-24636.
8. Cao ZJ, Xie Y, Dai C, Li WX§. Cloning and characterization of a novel calcium channel toxin-like gene BmCa1 from Chinese scorpion Mesobuthus martensii Karsch. Peptides 2006, 27 (6): 1235-1240
9. Sha YG, Wu YL, Cao ZJ, Xu XL, Wu WL, Jiang DH, Mao X, Liu H, Li WX*. A convenient cell fusion assay for the study of SARS-CoV entry and inhibition. IUBMB Life, 2006, 58(8):480-6.
10. Wanhong Liu,xiaohua He,Zhijian Cao ,Jiqun Sheng, Wenxin Li*. Efficient therapeutic gene expression in cutured rat hippocampal neurons mediated by human foamy virus vectors:a potential for the treatment of neurological diseases. Intervirology 2005, 48: 329-335.
11. Yingliang Wu, Zhijian Cao, Hong Yi, Dahe Jiang, Xin Mao, Hui Liu, Wenxin Li*. Simulation of the Interaction between ScyTx and small conductance calcium-activated potassium channel by docking and MM-PBSA. Biophy.J. 2004, 87: 105-112.
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