学习经历/Education
1999-2003：美国宾夕法尼亚大学, 博士后 / Postdoctoral Fellow, University of Pennsylvania
1996-1999：中科院微生物学所, 微生物学 博士 / Ph.D. in Microbiology, Institute of Microbiology, CAS, China.
1987-1990：武汉大学 病毒学 硕士 / M.S. in Virology, Wuhan University, China.
1983-1987：四川大学 微生物学 学士 / B.S. in Microbiology, Sichuan University, China.
工作经历 / Work Experience
2005-至今：中科院武汉病毒研究所/病毒学国家重点实验室，学科组长,研究员/ PI, Professor, State Key Laboratory of Virology, Wuhan Institute of Virology, CAS. China.
2003-2005：美国Fox Chase 癌症中心 研究助理 / Research Associate in Fox Chase Cancer Center, USA.
1990-1996：大连医科大学大学，讲师 / Lecture, Dalian Medical University, China
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近期代表性学术论文 / Selected Recent Publications
1. Liu L, Liu S, Jiang L, Chen X, Guo L, Che Y. Chloropupukeananin, the First Chlorinated Pupukeanane Derivative and Its Precursors from Pestalotiopsis fici. Org Lett. 2008 Apr 3;10(7):1397-400.
2. Li E, Tian R, Liu S, Chen X*, Guo L, Che Y*. Pestalotheols A-D, Bioactive Metabolites from the Plant Endophytic Fungus Pestalotiopsis theae. J Nat Prod. 2008 Apr; 71(4):664-8.
3. Zhang YG， Tian RR， Liu SC， Chen X， Liu XZ， Che YS. Alachalasins A-G, new cytochalasins from the fungus Stachybotrys charatum. Bioorg Med Chem. 2008. Mar 1;16(5):2627-34.
4. Singh LR, Chen X, Kozich V, Kruger WD. 2007. Chemical chaperone rescue of mutant human cystathionine beta-synthase. Mol Genet Metab. 91(4):335-42.
5. Chen X, Wang L, Fazlieva R, Kruger WD. 2006. Contrasting behaviors of mutant cystathionine beta-synthase enzymes associated with pyridoxine response. Hum Mutat. 27(5):474-82.
6. Dorjsuren D, Burnette A, Gray GN, Chen X, Zhu W, Roberts PE, Currens MJ, Shoemaker RH, Ricciardi RP, Sei S. 2006. Chemical library screen for novel inhibitors of Kaposi's sarcoma-associated herpesvirus processive DNA synthesis. Antiviral Res. 69(1):9-23.
7. Ricciardi RP, Lin K, Chen X, Dorjsuren D, Shoemaker R, Sei S. 2005. Rapid screening of chemical inhibitors that block processive DNA synthesis of herpesviruses: potential application to high-throughput screening. Methods Mol Biol. 292:481-92.
8. Wang L, Chen X, Tang B, Hua X, Klein-Szanto A, Kruger WD. 2005. Expression of mutant human cystathionine beta-synthase rescues neonatal lethality but not homocystinuria in a mouse model. Hum Mol Genet. 14(15):2201-8.
9. Chen X, Jhee KH, Kruger WD. 2004. Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine. J Biol Chem. 279(50):52082-6.
10. Chen X, Lin K, Ricciardi RP. 2004. Human Kaposi's sarcoma herpesvirus processivity factor-8 functions as a dimer in DNA synthesis. J Biol Chem. 279(27):28375-86.
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