张翼教授,博导、教育部“新世纪人才”

武汉大学教授、博士生导师
Professor, Wuhan University
  

学习经历/Education


1992 学士学位,南开大学/ B.S., Nankai University, China.

2000 博士学位,美国新泽西州医药与牙科大学,Rutgers大学(联合培养)/Ph.D. University of Medicine and Dentistry of New Jersey (UMDNJ) & Rutgers University, USA.

学术兼职/Committee and Broad Memberships

1. 第三界全国RNA会议暨第一届国际RNA研讨会, 组委和执行主席/3rd Annual Meeting of the China RNA Society & 1st International RNA Workshop in China, organizer

2. 中国生物化学与分子生物学协会RNA专业委员会委员/ Committee member of the Chinese Society of Biochemistry and Molecular Biology-RNA branch

3. 湖北省生物化学与分子生物学协会理事会理事/Director of the Council of Hubei Society of Biochemistry and Molecular Biology

4. 《中国生物化学与分子生物学》编委/Member, Editor board of Chinese Journal of Biochemistry and Molecular Biology





研究方向/Research Interests

1. 用I型内含子核酶为模型研究RNA的折叠机制,晶体结构和结构预测/Folding mechanisms, structures and phylogeny of group I intron ribozymes

2. 乙肝病毒RNA可变剪接调控,miRNA调控及抗病毒应用/Regulation of HBV gene expression by alternative splicing and miRNA targeting, and the related anti-HBV strategies.

3. 人类pre-mRNA可变剪接调控机制,及其与癌症等疾病的关系/The alternative splicing regulation and network in normal and diseased human cells

4. miRNA和其他非编码RNA的鉴定,调控机制,及其与发育和疾病的关系/Mammalian gene regulation by miRNA and other non-coding RNA

5. 微生物分子遗传/Microbial molecular genetics


代表性学术论文/Selected Publications


1. Sun T, Zhang Y*. (2008) Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translation. Nucleic Acids Research 36:1654-1664

2. Yu Zhou, Chen Lu, Qi-Jia Wu, Yu Wang, Zhi-Tao Sun, Jia-Cong Deng and Yi Zhang*. (2008) GISSD: Group I Intron Sequence and Structure Database. Nucleic Acids Research 36:D31-D37.

3. Wen-ping Tong, Yu Zhoua, Xinxin Wang, Fan Yang, Kai-Lang Wu, Jianguo Wu and Yi Zhang*. (2008) An accurate quantitative method for screening effective siRNA probes targeting a Hepatitis B virus transcript in single living cells. Biochemical and Biophysical Research Communications. 367 (4):866-873

4. Coutinho-Mansfield GC, Xue Y, Zhang Y, Fu XD (2007) PTB/nPTB switch: a post-transcriptional mechanism for programming neuronal differentiation. Genes & Development 21(13):1573-1577.

5. H. Lin, T-Y. Li, M-H. Xie, Y. Zhang* (2007) Characterization of the variants, flanking genes and promoter activity of Leifsonia xyli subsp. cynodontis insertion sequence IS1237. Journal of Bacteriology 189:3217-3227

6. Q. Meng, Y. Zhang, X-Q. Liu. (2007) Rare group I intron with insertion sequence element in a bacterial ribonucleotide reductase gene. Journal of Bacteriology 189:2150-2154.

7. P. Yin, T-Y. Li, M-H. Xie, L. Jiang, Y. Zhang*. (2006) A type Ib ParB protein involving in plasmid partitioning in a gram-positive bacterium. Journal of Bacteriology 188:8103-8108.

8. Y-F. Jiang, M. Xiao, P. Yin and Y. Zhang*. (2006) Monovalent cations use multiple mechanisms to resolve ribozyme misfolding. RNA 12:561-566.

9. M. Xiao, T. Li, X. Yuan, Y. Shang, F. Wang, S. Chen and Y. Zhang*. (2005) A peripheral element assembles the compact core structure essential for group I self-splicing. Nucleic Acids Research 33:4602-4611.

10. J. Wu, J. Zhou, F. Qu, P. Bao, Y. Zhang, Ling Peng. (2005) Polycationic dendrimers interact with RNA molecules: polyamine dendrimers inhibit the catalytic activity of Candida ribozymes. Chemical Communications (Camb). 2005(3):313-315. (Inside cover)

11. Z. Li and Y. Zhang*. (2005) Predicting the secondary structures and tertiary interactions of 211 group I introns in IE subgroup. Nucleic Acids Research 33:2118-2128.

12. L. Zhang, M. Xiao, C. Lu and Y. Zhang*. (2005) Fast formation of the P3-P7 pseudoknot: a strategy for efficient folding of the catalytically active ribozyme. RNA 11:58-69.

13. M. Xiao, MJ. Leibowitz and Y. Zhang*. (2003) Concerted folding of a Candida ribozyme to the catalytically active structure posterior to a rapid RNA compaction. Nucleic Acids Research 31:3901-3908. (Cover)


联系方式/Contact Information
电话/Tel: 86-27-68756207 (ext 21) (O); 86-27-68756207 (ext 20) (Lab);传真/Fax: 86-27-68754945
电子邮箱/E-mail: yizhang@whu.edu.cn

 

 

病毒学国家重点实验室(2004DA105204)
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