工作经历 / Work Experience

1954 -1986：中国科学院微生物研究所研究实习员至副研究员, Research Assistant to Associated Professor。

1986 -至今：中国科学院微生物研究所研究员 / Professor, Institute of Microbiology, CAS。

1991年：当选中国科学院院士 / Member of Chinese Academy of Sciences, 1991。

2001-至今： 武汉大学教授 / Professor, Wuhan University, China。

学术兼职 / Committee and Broad Memberships

1. 病毒学国家重点实验室学术委员会名誉主任 / Honored President, Broad Committee of the State Key Laboratory of Virology, China

2. 中国科学院微生物研究所学术委员会委员 / Member of Broad Committee of the Institute of Microbiology, Chinese Academy of Sciences.

近期代表性学术论文 / Selected Recent Publications

1. Yan Su，Huaiyi Yang, Baojiang Zhang, Xiaoxuan Qi, Po Tien* (2008) , A dual reporter gene based system to quantitate the cell fusion of avian influenza virus H5N1, Biotechonology letter，30: 73-79.

2. Yan Su, Xiaodong Zhu, Yao Wang, Min Wu, Po Tien* (2008), Evaluation of the Glu11 and Gly8 of H5N1 influenza hemagglutinin fusion peptide for membrane fusion using reverse genetics, Archives of Virology，153(2):247-57.

3. Chang-Mei Liu, Zhuo Yang, Chao-Wu Liu, Rong Wang, Po Tien* (2008), Roderick Dale and Lun-Quan Sun. Myostatin antisense RNA-mediated muscle growth in normal and cancer cachexia mice. Gene Therapy 15(3):155-60.

4. Jiabin Yan, Xuqing Liu, Yao Wang, Xiaomo Jiang, Huayu Liu, Mingying Wang, Xiaodong Zhu, Min Wu and Po Tien* (2007)，Enhancing the potency of HBV DNA vaccines using fusion genes of HBV specific antigens and the N-terminal fragment of gp96. Journal of Gene Medicine, 9: 107-121.

5. Yuxia Zhang, Shu Li, Ming Shan, Xuwen Pan, Ke Zhuang, Lihua He, Keith Gould and Po Tien* (2007), HBV core antigen epitopes presented by HLA-A2 single chain trimers induce functional epitope-specific CD8+ T cell responses in HLA-A2.1/Kb transgenic mice, Immunology, 121(1): 105-12.

6. Shuwen Wu, Junqiang Xu, Jiangxia Liu, Xuan Yan, Xiaodong Zhu, Gengfu Xiao, Lunquan Sun, Po Tien* (2007), An efficient RNA-cleaving DNA enzyme can specifically target the 5’-untranslated region of Severe Acute Respiratory Syndrome associated Coronavirus (SARS-CoV). Journal of Gene Medicine, 9: 1080-1086.

7. Heng-Gui Liu, Chen Wei-Wei, Fan Zhen-Ping, Yang Hui-Ying, Shi Ming, Zhang Zheng, Luan Shen-Shun, Zhang Hui, Lu Peng, Po Tien*, Wang Fu-Sheng (2007). The high prevalence of the 127 mutant HBsAg18-27 epitope in Chinese HBV-infected patients and its cross-reactivity with the V27 prototype epitope. Clinical Immunology，125, 337-345.

8. Chang-Mei Liu, Zhuo Yang, Chao-Wu Liu, Rong Wang, Po Tien* (2007), Roderick Daleb and Lun-Quan Sun. Effect of RNA oligonucleotide targeting Foxo-1 on muscle growth in normal and cancer cachexia mice. Cancer Gene Therapy，14(12): 945-52.

9. Wenbin Yang, Huaiyi Yang, Po Tien* (2006). In Vitro Self-propagation of Recombinant PrPSc-like Conformation Generated in the Yeast Cytoplasm. FEBS Letters, 580: 4231-4235.

10. Minghai Zhou, Dongping Xu, Xiaojuan Li, Hongtao Li, Ming Shan, Jiaren Tang, Min Wang, Fu-Sheng Wang, Xiaodong Zhu, Hua Tao, Wei He, Po Tien*, and George F. Gao (2006), Screening and Identification of Severe Acute Respiratory Syndrome-Associated Coronavirus-Specific CTL Epitopes, Journal of Immunology, 177(4): 2138-2145.

11. Xiaoyan Gong, Xien Gui, Yuxia Zhang, Po Tien* (2006). Screening for CD8 cytotoxic T lymphocytes specific for Gag of human immunodeficiency virus type 1 subtype B’ Henan isolate from China and identification of novel epitopes restricted by the HLA-A2 and HLA-A11 alleles. Journal of General Virology, 87: 151-158.

12. Yueyong Liu, Yanhui Xu, Zhiyong Lou, Jieqing Zhu, Xuebo Hu, George F. Gao, Bingsheng Qiu, Zihe Rao, Po Tien* (2006), Structural characterization of Mumps virus fusion protein core. Biochemical and Biophysical Research Communications, 348: 916-922.