病毒学国家重点实验室主任/Director, State Key Laboratory of Virology
教育部“长江学者奖励计划”病毒学特聘教授/Chair Professor of Virology, Cheung Kong Scholar Program, Ministry of Education
武汉大学教授、博士生导师/Professor, Wuhan University
学习经历 / Education
1993-1996：美国普林斯顿大学 分子生物学 博士后 / Postdoctoral Associate in Molecular Biology, Princeton University, USA.
1989-1992：美国爱达华大学 生物化学 博士 / Ph.D. in Biochemistry, University of Idaho, USA.
1982-1985：武汉大学 病毒学 硕士 / M.S. in Virology, Wuhan University, China.
1978-1982：武汉大学 微生物学 学士 / B.S. in Microbiology, Wuhan University, China.
工作经历 / Work Experience
2005-至今：病毒学国家重点实验室，主任 / Director, State Key Laboratory of Virology, China.
2004-至今：武汉大学艾滋病中心，副主任 / Associate Director, Wuhan University AIDS Center, China.
1999-至今：教育部“长江学者奖励计划”，病毒学特聘教授 / Chair Professor of Virology, Cheung Kong Scholars Program, Ministry of Education, China.
1999-至今：武汉大学，教授 / Professor, Wuhan University, Wuhan, China.
2002-2004：美国海军健康研究中心分子生物学实验室，主任 / Director, Molecular Biology Laboratory, Naval Health Research Center, USA.
1999-2002：美国多瑞玛斯研究所，资深研究员 / Senior Scientist, Torry Mesa Research Institute, USA.
1996-1999：美国普林斯顿大学，研究员 / Research Staff Member, Princeton University, USA.
1992-1993：美国爱达华大学，副研究员 / Research Associate, University of Idaho, USA
1986-1989：美国佐治亚大学，访问学者 / Visiting Scholar, University of Georgia, USA
1985-1986：武汉大学，讲师 / Lecture, Wuhan University, China
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近期代表性学术论文 / Selected Recent Publications
1. Lu LL, Wei L, Peng GQ, Mu YX, Wu KL, Kang L, Yan XH, Zhu Y, Wu JG* (2008). NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways. Virology 371:61-70.
2. Rasool ST, Tang H, Wu JM, Li W, Mukhtar MM, Zhang JW, Mu YX, Wu JG*, Zhu Y (2008). Increased level of IL-32 during human immunodeficiency virus infection suppresses HIV replication. Immunol Lett 117:161-167.
3. Feng Y, Wang SQ, Luo FL, Ruan Y, Kang L, Xiang XH, Peng GQ, Zhu CL, Yongxin Mu YX, Zhang XL, Wu JG* (2008). A novel recombinant bacterial vaccine strain expressing dual viral antigens induces multiple immune responses to the gag and gp120 proteins of HIV-1 in immunized mice. Antivir Res doi:10.1016/j.antiviral.2008.06.013. (In press)
4. Li W, Liu Y, Mukhtar MM, Rasool ST, Gao YC, Gong R, Hao Q, Peng GQ, Chen YN, Wu JG*, Zhu Y (2008). Activation of interleukin-32 proinflammatory pathway in response to influenza A virus infection. PLoS ONE 3(4): e1985.
5. Mukhtar MM, Li SF, Li W, Wan T, Mu YX, Wei W, Kang L, Rasool ST, Xiao YB, Zhu Y, Wu JG* (2008). Single-chain intracellular antibodies inhibit influenza virus replication by disrupting interaction of proteins involved in viral replication and transcription. Int J Biochem Cell Biol doi:10.1016/j.biocel.2008.07.001 (In press). 6. Liu M, Yang YB, Gu CF, Yue YP, Wu KK, Wu JG*, Zhu Y (2007). Spike protein of SARS-CoV stimulates cyclooxygenase-2 expression via both calcium-dependent and calcium-independent protein kinase C pathways. FASEB J 21(7):1586-1596.
7. Zhang X, Wu KL, Wang D, Yue X, Song DG, Zhu Y, Wu JG* (2007). Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-kappaB. Virology 365(2):324-335.
8. Peng GQ, Zhang FM, Zhang Q, Wu KL, Zhu F, Wu JG* (2007). Borna disease virus P protein inhibits nitric oxide synthase gene expression in astrocytes. Virology 366:446-452.
9. Wu KL, Mu YX, Hu J, Lu L, Zhang X, Yang YB, Li Y, Liu F, Song DG, Zhu Y, Wu JG* (2007). Simultaneously inhibition of HIV and HBV replication through a dual small interfering RNA expression system. Antivir Res 74:142-149.
10. Pan Y, Wei W, Kang L, Wang ZQ, Fang JL, Zhu Y, Wu JG* (2007). NS5A protein of HCV enhances HBV replication and resistance to interferon response. Biochem Biophys Res Commun 359(1):70-75.
11. Wei W, Huang WJ, Pan Y, Zhu F, Wu JG* (2006). Functional switch of viral protein HBx on cell apoptosis, transformation, and tumorigenesis in association with oncoprotein Ras. Cancer Lett 244(1):119-128.
12. Yan XH, Hao Q, Mu YX, Timani KT, Ye LB, Zhu Y, Wu JG* (2006). Nucleocapsid protein of SARS-CoV activates the expression of cyclooxygenase-2 by binding directly to regulatory elements for nuclear factor-kappa B and CCAAT/enhancer binding protein. Int J Biochem Cell Biol 38(8):1417-1428.
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