实验室重大研究成果 1. “卵寄生蜂传递病毒防治害虫新技术”获国家科学技术发明二等奖 2. “东亚钳蝎毒素组学研究”获湖北省自然科学一等奖 3. “流行性出血热病原学、分子流行病学与抗病毒治疗研究”获湖北省科技进步二等奖         国内外期刊重要论文 1. Yu Zhou, Chen Lu, Qi-Jia Wu, Yu Wang, Zhi-Tao Sun, Jia-Cong Deng and Yi Zhang*. 2008. GISSD: Group I Intron Sequence and Structure Database. Nucleic Acids Research. 310: D31-D37. (IF: 6.317) 2. Gabriela C. Coutinho-Mansfield, Yuanchao Xue, Yi Zhang*, and Xiang-Dong Fu . 2007. PTB/nPTB switch: a post-transcriptional mechanism for programming neuronal differentiation. Genes & Dev. 21: 1573-1577. (IF:15.05) 3. Xiaoxue Peng, Ji'an Pan, Rui Gong, Yang Liu, Shuli Kang, Huixing Feng, Gang Qiu, Deyin Guo, Po Tien, and Gengfu Xiao*. 2007. Functional Characterization of Syncytin-A, a Newly Murine Endogenous Virus Envelope Protein IMPLICATION FOR ITS FUSION MECHANISM. J.Biol.Chem. 282: 381–389. (IF:5.808) 4. Feici Diao, Shu Li, Yang Tian, Min Zhang, Liang-Guo Xu, Yan Zhang, Rui-Peng Wang, Danying Chen ,Zhonghe Zhai, Bo Zhong, Po Tien*, and Hong-Bing Shu*. 2007. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. Proc. Natl. Acad. Sci. USA. 104: 11706–11711. (IF:9.643) 5. Hong Yi, Zhijian Cao, Shijin Yin, Chao Dai, Yingliang Wu* and Wenxin Li*. 2007. Interaction Simulation of hERG K+ Channel with Its Specific BeKm-1 Peptide: Insights into the Selectivity of Molecular Recognition. J. Proteome . Res. 6: 611-620. (IF:5.151) 6. Fei Deng, Ranran Wang, Minggang Fang, Yue Jiang,Xushi Xu,Hanzhong Wang, Xinwen Chen, Basil M. Arif,Lin Guo,Hualin Wang,and Zhihong Hu*. 2007. Proteomics Analysis of Helicoverpa armigera Single Nucleocapsid Nucleopolyhedrovirus Identified Two New Occlusion-Derived Virus-Associated Proteins, HA44 and HA100. J. Virol. 81: 9377–9385. (IF:5.341) 7. BYufeng Zhanga, Jianhua Songb, Bin Shia, Yining Wanga, Xiaohui Chena, Cui Huanga, Xuecao Yanga, Dongxuan Xua, Xiangrong Chenga, Xinwen Chen*. 2007. Combination of scaffold and adenovirus vectors expressing bone morphogenetic protein-7 for alveolar bone regeneration at dental implant defects. Biomaterials 28: 4635–4642. (IF:5.196) 8. Hong Zheng, Linbai Ye*, Xiaonan Fang, Baozong Li, Yuhua Wang, Xiaoxiao Xiang, Lingbao Kong, Wei Wang, Yinchun Zeng, Li Ye, Zhenghui Wu, Yinglong She, and Xiaolin Zhou. 2007. Torque Teno Virus (SANBAN Isolate) ORF2 Protein Suppresses NF-kB Pathways via Interaction with IkB Kinases. J. Virol. 81 : 11917–11924. (IF:5.341) 9. Mo Liu, Yongbo Yang, Chunfang Gu, Yinpu Yue, Kenneth K. Wu, Jianguo Wu*, and Ying Zhu*. 2007. Spike protein of SARS-CoV stimulates cyclooxygenase-2 expression via both calcium-dependent and calciumindependent protein kinase C pathways. FASEB J. 21: 1586–1596. (IF:6.721) 10. YAN-FEI JIANG, MU XIAO, PING YIN, and YI ZHANG* . 2006. Monovalent cations use multiple mechanisms to resolve ribozyme misfolding. RNA . 12 : 561–566. (IF:6.145) 11. You-Yi Huang, Jiao-Yu Deng, Jing Gu, Zhi-Ping Zhang, Anthony Maxwell, Li-Jun Bi, Yuan-Yuan Chen ,Ya-Feng Zhou, Zi-Niu Yu and Xian-En Zhang*. 2006. The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA). Nucleic Acids Research. 34: 5650–5659. (IF:7.552) 12. Yong-Chao Guo, Ya-Feng Zhou, Xian-En Zhang*, Zhi-Ping Zhang, Yan-Mei Qiao, Li-Jun Bi, Ji-Kai Wen, Mi-Fang Liang and Ji-Bin Zhang. 2006. Phage display mediated immuno-PCR. Nucleic Acids Research. 34: e62. (IF:7.552) 13. Shi-Hua Wang, Ji-Bin Zhang, Zhi-Ping Zhang, Ya-Feng Zhou, Rui-Fu Yang, Jia Chen, Yong-Chao Guo, Fan You, and Xian-En Zhang*. 2006. Construction of Single Chain Variable Fragment(ScFv) and BiscFv-Alkaline Phosphatase Fusion Protein for Detection of Bacillus Anthracis. Anal. Chem. 78: 997-1004. (IF:5.635) 14. Fan You, Ya-Feng Zhou, Xian-En Zhang*, Zhi Huang, Li-Jun Bi, Zhi-Ping Zhang, Ji-Kai Wen, Yuan-Yuan Chen, Gui-Bin Jiang and Ming-Hui Zheng. 2006. Cell-Free Bioassay for Measurement of Dioxins Based on Fluorescence Enhancement of Fluorescein Isothiocyanate-Labeled DNA Probe. Anal. Chem. 78: 7138-7144. (IF:5.635) 15. Gang Long, Xiaoyu Pan, Marcel Westenberg and Just M. Vlak*. 2006. Functional Role of the Cytoplasmic Tail Domain of the Major Envelope Fusion Protein of Group II Baculoviruses. J. Virol. 80: 11226–11234. (IF: 5.178) 16. Gang Long, Xiaoyu Pan, Richard Kormelink and Just M. Vlak*. 2006. Functional Entry of Baculovirus into Insect and Mammalian Cells Is Dependent on Clathrin-Mediated Endocytosis. J. Virol. 80: 8830–8833. (IF:5.178) 17. Fang Yang Jr, Min Zhang, Bing-Rui Zhou, Jie Chen and Yi Liang*. 2006. Oleic Acid Inhibits Amyloid Formation of theIntermediate of α-Lactalbumin at Moderately Acidic pH. J. Mol. Biol. 362: 821–834. (IF:5.229) 18. Fen Du, Zheng Zhou, Zhong-Ying Mo, Jun-Zhi Shi, Jie Chen and Yi Liang*. 2006. Mixed Macro-molecular Crowding Accelerates the Refolding of Rabbit Muscle Creatine Kinase: Implications for Protein Folding in Physiological Environments. J. Mol. Biol. 364: 469–482. (IF:5.229) 19. Ming-Xiong Guo, Di Wang, Huan-Jie Shao, Hong-Ling Qiu, Lu Xue , Zhou-Zhou Zhao, Chen-Gang Zhu, Yun-Bo Shi and Wen-Xin Li*. 2006. Transcription of Human Zinc Finger ZNF268 Gene Requires an Intragenic Promoter Element. J.Biol.Chem . 281: 24623–24636. (IF:5.854) 20. Yong Zhang, Lin Lu, Lei Ba, Li Liu, Li Yang, Manhong Jia, Haibo Wang, Qing Fang, Yuhua Shi, Wenyun Yan,Guangcai Chang, Linqi Zhang, David D. Ho, Zhiwei Chen*. 2006.Dominance of HIV-1 Subtype CRF01_AE in Sexually Acquired Cases Leads to a New Epidemic in Yunnan Province of China.PLoS Medicine 3:2065-2077.(IF:8.389)           专著 1. Regulation of Gene expression in "Bioinformatic:A Practical Approach 章晓联 参编 Taylor and Francis Group,LLC 2007,PP219-250 2. 医学免疫学 章晓联 主编 武汉大学出版社 2007           专利     申请人 专利名称 专利号 专利类别 内容 陈则 预防流感病毒的截短的血凝素疫苗及其制备方法 ZL200410061206.1 发明专利 查看 方勤 、丁清泉 草鱼呼肠孤病毒抗原亚单位疫苗制备方法 ZL2004100608812 发明专利 查看 胡先明 、龚晓艳、邱国福、何建社 光学纯N-甲基-3-苯基-3-羟基丙胺的制备方法 ZL02139006.1 发明专利 查看 梁毅 、刘冲、项瑾、廖俊明、周拯、杜立群、张鹏、周兵瑞、王晓东、范俊宝、杜芬、陈杰 筛选G蛋白偶联受体药物的方法及装置 ZL200510018825.7 发明专利 查看 庞代文*、谢敏、张志凌、杜予民 一种糖生物功能化的水溶性量子点的制备方法-相转移法 ( 超声法 ) ZL200510018234.x 发明专利 查看 庞代文*、鲁哲学、张志凌 量子点纳米二氧化钛复合膜的制备方法 ZL200510018188.3 发明专利 查看 庞代文*、谢敏、张志凌、杜予民 一种糖生物功能化的水溶性量子点的制备方法-研磨法 ZL200510018233.5 发明专利 查看 孙慧、齐义鹏、仝鑫、赵辰光、梁一 一种真菌半乳糖凝集素蛋白活性的多肽、其编码序列及制备方法和应用 ZL200510018623.2 发明专利 查看 王汉中、陈新文、胡志红 带有棉铃虫单粒包埋核型多角体病毒基因核P10基因启动子序列的快速供体质粒及构建方法 ZL01138376.3 发明专利 查看 杨占秋、熊海蓉、何静、石丽桥、关意洪、肖红 一种抗呼吸道病毒的药物及用途 ZL200510018613.9 发明专利 查看 叶林柏、吴正辉、佘应龙、叶力、郜金荣 一种生产重组人tPA的工程菌株及制备方法 ZL200510019708.2 发明专利 查看 叶林柏、吴正辉、佘应龙、叶力、郜金荣 一种重组人tPA的制备方法 ZL200510019706.3 发明专利 查看 叶林柏、吴正辉、佘应龙、叶力、郜金荣 一种表达重组人tPA的质粒及构建方法 ZL200510019707.8 发明专利 查看 张先恩、游璠、周亚凤、郭永超、张治平 一种检测二恶英的单链抗体方法 ZL200510019329.3 发明专利 查看 张翼、张礼斌 抗白色念珠菌感染的反义寡核苷酸序列及其应用 ZL200510019317.0 发明专利 查看 郑从义、顾潮江、屈三甫 一种检测口蹄疫病毒的荧光定量PCR试剂盒及应用 ZL200410061422.6 发明专利 查看 章晓联、叶新山、孙芳、张礼和 氮杂糖类化合物，它们的合成方法，以及作为免疫抑制剂和糖苷酶抑制剂的用途 03156099.7 发明专利 查看 章晓联、瞿少刚、周翔、吴建国、陈明、李平飞 细胞因子IL-24真核表达载体的构建及应用 ZL200410060813.6 发明专利 查看 章晓联、罗风玲、洪勇、吴建国、朱应 染色体上携带病毒基因的减毒伤寒杆菌疫苗及制备方法 ZL200510018480.5 发明专利 查看 周亚凤、张先恩、游璠、黄智、张治平 一种搞通量监测环境中二恶英类化学物质的方法 ZL200510018969.2 发明专利 查看 王业富、曹轩 快速检测细小脲原体的荧光定量PCR试剂盒 2006100187672 发明专利 查看 王业富、曹轩 快速检测沙眼衣原体的荧光定量PCR试剂盒 2006100187668 发明专利 查看 王业富、曹轩 同步检测沙眼衣原体河西小脲原体的荧光定量PCR试剂盒 2006100187687 发明专利 查看

病毒学国家重点实验室(2004DA105204)
湖北 武汉 430072
电话：(8627)-68754979　传真：(8627)-68752592
电子邮件：voskl@chinalab.gov.cn
Copyright ©2005-2006 virology.chinalab.gov.cn